活性氧Podocarpusflavone A，CAS No. 22136-74-9

产品名称：活性氧Podocarpusflavone A，CAS No. 22136-74-9

产地：西安
规格：1mg 5mg 10mg
纯度：99%
用途：仅用于科研
状态：固体/粉末
储藏条件：冷藏-20℃

罗汉果黄酮A是一种双黄酮，在罗汉果中发现，具有多种生物活性。它抑制登革热病毒NS5 RNA依赖性RNA聚合酶（DENV-NS5 RdRp；IC50=0.75µM）。罗汉果总黄酮A还抑制组织蛋白酶B，IC50值为1.68µM，并在报告基因分析中以浓度依赖的方式抑制STAT3。它减少了活性氧的产生当在1和10µM的浓度下使用时，由佛波醇12-肉豆蔻酸酯13-乙酸酯（PMA）在分离的人类中性粒细胞中诱导的物种（ROS）和超氧化物阴离子，4在无细胞测定中，罗汉果黄酮A还抑制淀粉样蛋白-β（1-40）肽（Aβ40）的聚集，IC50值为4.9μM。5罗汉果黄素A（20µM）在20和40 mg/kg剂量下给药时，降低A375、MALME-3M、SK-MEL-1和SK-MEL-5黑色素瘤细胞的活力，并减少A375小鼠异种移植物模型中的肿瘤生长。

Momordica grosvenorii flavone A is a kind of double flavone, which is found in Momordica grosvenorii and has a variety of biological activities. It inhibits dengue virus NS5 RNA dependent RNA polymerase (DENV-NS5 RdRp; IC50=0.75 µ M). The total flavone A of Siraitia grosvenorii also inhibits cathepsin B, with an IC50 value of 1.68 µ M, and inhibits STAT3 in a concentration dependent manner in the reporter gene analysis. It reduces the production of reactive oxygen species (ROS) and superoxide anions induced by phorbol 12 myristate 13 acetate (PMA) in isolated human neutrophils when used at concentrations of 1 and 10 µ M. 4 In cell-free assay, momordica grosvenorii flavone A also inhibits amyloid protein- β (1-40) Peptide (A β Aggregation of 40) with an IC50 value of 4.9 μ M。 5 Siraitin A (20 µ M), when administered at 20 and 40 mg/kg doses, decreased the activity of A375, MALME-3M, SK-MEL-1 and SK-MEL-5 melanoma cells, and reduced tumor growth in A375 mice xenograft model.

编辑：XAQYBIO HAO，2023年4月23日。