Button 放在UpdatePanel 之后就不执行 onclick？

今天在测试以前做一个网站，网页的代码为：

<form id="form1" runat="server">
    <div>
    <ul>
       <li>
           <asp:ScriptManager ID="ScriptManager1" runat="server">
           </asp:ScriptManager>
           <asp:TextBox ID="TextBox_Title" runat="server" Width="400px">标题</asp:TextBox><asp:Label ID="Label_Id" runat="server" Visible="False"></asp:Label>
           <asp:UpdatePanel ID="UpdatePanel_Article" runat="server" RenderMode="Inline">
            <ContentTemplate>
                <span class="Text_Blue" style="font-size: 10pt; color: #1c2f3e">隶属</span>&nbsp;<asp:DropDownList
                        ID="Drop_A_Cla" runat="server" AutoPostBack="True" OnSelectedIndexChanged="Drop_A_Cla_SelectedIndexChanged">
                    </asp:DropDownList>
                    <asp:DropDownList ID="Drop_A_Cla_2" runat="server" AutoPostBack="True" OnSelectedIndexChanged="Drop_A_Cla_2_SelectedIndexChanged"
                        Visible="False">
                        <asp:ListItem Value="0">所有大类</asp:ListItem>
                    </asp:DropDownList>
                    <asp:DropDownList ID="Drop_A_Cla_3" runat="server" Visible="False">
                        <asp:ListItem Value="0">所有小类</asp:ListItem>
                    </asp:DropDownList>
                  
            </ContentTemplate>
        </asp:UpdatePanel>
        </li>
        <li><asp:TextBox ID="FreeTextBox_Content" runat="server" Height="400px"
                TextMode="MultiLine" Width="770px"></asp:TextBox></li>
       
        <li><asp:Button ID="Button_up" runat="server" OnClick="Button_up_Click" Text="提交"  CssClass="Btn"  /></li>
        </ul>
        </div>
    </form>

发现点发击提交按钮没反应，经过N小时的测试发现，只要选择栏目后就不能成功提交。后来又发现，打开网页后先选栏目，然后填标题和正文也可以提交，后来又发现，只要最后点一下标题的文本框就可以成功提交，最后汇总发现只要将按钮放在第一个，也可以正功提交。真是奇了怪了。不死心，遂用谷歌浏览器调试，发现可以正常运行，根本不存在IE9下出现的问题。人顿时无语了……