只运行一个实例的例程

static System.Threading.Mutex mutex;   //定义成员变量

 static void Main()

        {
            try
            {
                string processName = "Global\\Test.TestSingle";   //关键点在于Global，如果不加Global\\,则只能一个用户下有用，多个用户没用。
                                                                                                          //只能在管理员权限运行，非管理员权限会报错。
                bool createdNew = false;
                mutex = new System.Threading.Mutex(true, processName, out createdNew);
                if (createdNew)
                {

                    try
                    {
                        Application.EnableVisualStyles();
                        Application.SetCompatibleTextRenderingDefault(false);
                        Application.Run(new Form1());
                    }
                    catch (Exception ex)
                    {
                        MessageBox.Show(ex.ToString(), "系统提示");
                    }
                    finally
                    {
                        mutex.ReleaseMutex();
 
                    }
                }
                else
                {
                    DialogResult dr = MessageBox.Show("系统已经运行了一个实例!\r\n", "系统提示", MessageBoxButtons.YesNo, MessageBoxIcon.Question, MessageBoxDefaultButton.Button2);
                }

            }
            catch (Exception ex)
            {
                MessageBox.Show(ex.ToString(), "系统提示");
            }

        }

为了避免在远程桌面启动多个程序，可以调用C#的SystemInformation.TerminalServerSession，判断远程桌面时，不让启动程序。
如：
if (SystemInformation.TerminalServerSession)
                {
                    MessageBox.Show("远程桌面登录时,禁止启动系统，请本机登录启动", "系统提示");
                    return;
                }