(4E)-反式环辛烯-活性酯，(4E)-TCO-NHS ester，适合与抗体、蛋白质或探针结合

最新推荐文章于 2024-08-05 09:48:26 发布

PEG的工厂

最新推荐文章于 2024-08-05 09:48:26 发布

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(4E)-反式环辛烯-活性酯，(4E)-TCO-NHS ester，1191901-33-3，适合与抗体、蛋白质或探针结合，可以与四嗪反应形成稳定的二氢哒嗪键

文章关键词：(4E)-反式环辛烯-活性酯，(4E)-TCO-NHS ester，1191901-33-3

一、基本信息

【性质简介】：(4E) - TCO-NHS ester is a compound with unique properties, which can exist in solid or viscous liquid forms, mainly depending on the molecular weight of the PEG (polyethylene glycol) it binds to. In most cases, it presents a pure white solid form, giving people a fresh and delicate feeling. In the field of chemistry, the TCO component of (4E) - TCO-NHS ester exhibits impressive site-specific binding ability, which is achieved through click chemistry. This click chemistry method enables precise binding of (4E) - TCO-NHS ester with biomolecules such as antibodies, proteins, or probes, providing great convenience for biomedical research.

It is worth mentioning that the TCO part of the (4E) - TCO-NHS ester can react with tetrazine through a mechanism called anti electron demand Diels Alder cycloaddition reaction. This reaction process is not only efficient, but also capable of forming stable dihydropyridazine bonds, ensuring a stable connection between the (4E) - TCO-NHS ester and the target molecule. The formation of this stable dihydropyridazine bond provides a powerful tool for labeling, tracing, and detection in biomedical research. Whether in drug development, biological imaging, or protein interaction research, (4E) - TCO-NHS ester has demonstrated its unique value and broad application prospects.

【中文名】：(4E)-反式环辛烯-活性酯

【英文名】：(4E)-TCO-NHS ester

【CAS号】：1191901-33-3

【化学式】：C13H17NO5

【分子量】：267.28

【结构式】：