Thalidomide-amine，Thalidomide-NH2，可以与目标蛋白特异性结合

文章关键词：2415263-07-7，泊马度胺氨基，Thalidomide-O-amido-C8-NH2，Thalidomide-NH2，Thalidomide-amine

一、基本信息

【性质简介】：The reaction principle of Thalidomide-O-amido-C8-NH2 is mainly due to its unique properties as a synthesized E3 ligand-linker conjugate. This carefully designed coupling compound combines Thalidomide's cereblon ligand with a carefully crafted linker, working together to participate in and drive a series of fine chemical reactions. Thalidomide， As a validated and efficient ligand, it plays a crucial role in the reaction. It can bind specifically to target proteins such as cereblon. This combination is not accidental, but based on complex intermolecular interactions, such as precise formation of hydrogen bonds and clever utilization of hydrophobic interactions, ensuring a stable and strong link between Thalidomide and the target protein. The O-amido-C8-NH2 part, as a linker, plays a crucial bridging role in the entire reaction system. The design of Linker requires both effective connection with ligands and smooth binding with target molecules, while also maintaining the stability and activity of the entire molecule.

【中文名】：泊马度胺氨基

【英文名】：Thalidomide-O-amido-C8-NH2，Thalidomide-NH2，Thalidomide-amine

【CAS号】：2415263-07-7

【化学式】：C23H31ClN4O6

【分子量】：494.97

【结构式】：

 

​二、详情介绍

【外观】：固体/粉末

【溶解性】：溶于大部分有机溶剂

【规格】：1g、5g、10g

【纯度】：95%+

【储存条件】：本品应密封避光，储存于阴凉、干燥、通风处，避免反复冻融，储液应该立即使用

【注意事项】：试剂仅用于科学研究或者工业应用等非医疗目的，非药用，非食用！

三、相关试剂

N-azidoacetylmannosamine-tretraacylated ，Ac4ManNAz

N-azidoacetylgalactosamine-tetraacylated (Ac4GaINAz)

2-[(Azidoacetyl)amino]-2-deoxy-D-glucose

2-[(Azidoacetyl)amino]-2-deoxy-D-galactopyranose

2-Azido-2-deoxy-D-glucose

N3-PEG5-NHS，Azide PEG5 NHS

NHS-PEG5-NHS，Bis-PEG5-NHS ester

N3-PEG5-Tos，Azide PEG5 Tos

N3-PEG6-alcohol，N3 PEG6 OH，Azide PEG6 alcohol，Azide PEG6 OH

N3-PEG6-amine，N3-PEG6-NH2，Azide PEG6 amine，Azide PEG6 NH2

N3-PEG12-amine，N3-PEG12-NH2，Azide PEG12 amine，Azide PEG12 NH2

N3-PEG6-COOH，Azide PEG7 acid

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