(1) The dynamic changes of regional landscape indices can indicate the transformation of regional ecological functions, meanwhile, these characteristics of transformation changes among various landscape types are beneficial to reveal sustainability of land use and level of regional ecosystem function, to detect out change tendency of regional ecological environment and its inner factors. In this paper, land use change situation of Kitakyushu city in the past 15 years was analyzed by 11 indices. In summary, in view of land use landscape types, obvious difference of indices change existed in different landscape types, which demonstrated that distribution of land use types was inclined to more dispersed, decreasing connectivity among them and complicated spatial pattern. As a result, ecosystem stability of regional landscape and sustainability of land use were reduced. On the other hand, FN index decreased and AWMSI, FD, MPS and LPI increased, which showed land use tended to centralized distribution and complication, human activity enhanced development and exploitation degree of local land. Rising DI, decreasing SHDI and SHEI reflected that land use type appeared non-equalization in the spatial distribution. According to change of these landscape indices, ant-jamming ability of land use landscape and stability of entire ecosystem environment in Kitakyushu city were weakened. It’s evident that the following three reasons resulted in these changes. Firstly, population growth indirectly resulted in increasing of residence land and patch number. Secondly, industrialization and urbanization have been accelerated owing to development of regional economy, which has made land use change more extensively and diversely. Thirdly, policies driving resulted in which the region has been chiefly aiming at economic growth and ignoring reasonable adjustment of land use structure. Based on the above conclusions, it was recommended that mode of land use should be adjusted at landscape scale to rehabilitate and reconstruct the landscape ecosystems in Kitakyushu city.