When you open a window, let's say work repository editing, a small window pops up, and stuck at "Initializing Search Engine", it goes on and one. You cannot wait any longer, you have to kill ODI with windows process manager.
Remedy: Open ODI studio, View --> "Find ODI Object". And try to open something again.
Remedy: Open ODI studio, View --> "Find ODI Object". And try to open something again.