Isobutyl-deoxynyboquinone
CAS:1430798-22-3
品牌:MedChemExpress (MCE)
存储条件:Please store the product under the recommended conditions in the Certificate of Analysis.
生物活性:Isobutyl-deoxynyboquinone (IB-DNQ) 是 NAD(P)H:quinone oxidoreductase (NQO1) 的选择性底物。异丁基脱氧苯醌可用于抗癌研究[1]。
体外:Isobutyl-deoxynyboquinone (0.01~100 μM; OSCC 细胞) 对 SCCF1 和 SCCF2 细胞系表现出更强的细胞毒性,而对 SCCF3 细胞系的细胞毒性更弱。 Isobutyl-deoxynyboquinone(0.1~3 μM;60 分钟;SCCF1 细胞)以剂量依赖性方式诱导细胞毒性[1]。
体内:Isobutyl-deoxynyboquinone (0.5~2 mg/kg; iv; 20 hours) 达到平均峰值血浆浓度水平。异丁基-脱氧苯醌(1 mg/kg;口服;4 小时)达到血浆峰浓度[1]。
参考文献:
[1]. Lundberg AP, et al. Pharmacokinetics and derivation of an anticancer dosing regimen for the novel anti-cancer agent isobutyl-deoxynyboquinone (IB-DNQ), a NQO1 bioactivatable molecule, in the domestic felid species. Invest New Drugs. 2017;35(2):134-144.