BpV(HOpic) 是一种有效的选择性 PTEN 抑制剂 | MedChemExpress (MCE)

BpV(HOpic)

CAS：722494-26-0

品牌：MedChemExpress (MCE)

存储条件：-20°C, sealed storage, away from moisture

生物活性：BpV(HOpic) 是一种有效的选择性 PTEN 抑制剂，IC50 为 14 nM。 Nanocarrier-BpV(HOpic)具有神经保护活性[1][2]。 IC50 和靶标：IC50：14 nM (PTEN)。

体外：BpV(HOpic) (1 µM) 处理在接受顺铂处理的 MG63 细胞中增加细胞增殖并降低凋亡率[3]。
Bpv(HOpic) (1 µM) 增强 C2C12 成肌细胞的迁移并且与 PI3K/AKT 和 MAPK/ERK 信号通路的激活有关[4]。
BpV(HOpic)（1 µM；48 小时）促进猪卵泡生长发育的启动，与啮齿类动物和人类相似[5]。
纳米载体-BpV（HOpic）增强神经元的轴突生长[2]。

体内：BpV(HOpic) (0.05 mg/kg; ip) 在再灌注时改善体内肝缺血/再灌注 (I/R) 损伤[6]。
BpV(HOpic) (200 μg/ kg; ip) 在缺血/再灌注损伤 (IRI) 小鼠中加剧肾功能障碍并促进肾小管损伤[7]。

参考文献：

[1]. Schmid AC, et, al. Bisperoxovanadium compounds are potent PTEN inhibitors. FEBS Lett. 2004 May 21; 566(1-3): 35-8.
[2]. Zhang B, et, al. Silencing of miR-19a-3p enhances osteosarcoma cells chemosensitivity by elevating the expression of tumor suppressor PTEN. Oncol Lett. 2019 Jan; 17(1): 414-421.
[3]. Dimchev GA, et, al. Phospho-tyrosine phosphatase inhibitor Bpv(Hopic) enhances C2C12 myoblast migration in vitro. Requirement of PI3K/AKT and MAPK/ERK pathways. J Muscle Res Cell Motil. 2013 May; 34(2): 125-36.
[4]. Raffel N, et, al. The effect of bpV(HOpic) on in vitro activation of primordial follicles in cultured swine ovarian cortical strips. Reprod Domest Anim. 2019 Aug; 54(8): 1057-1063.
[5]. Ponte CD, et, al. Pharmacological postconditioning protects against hepatic ischemia/reperfusion injury. Liver Transpl. 2011 Apr; 17(4): 474-82.
[6]. Zhou J,et, al. Pharmacological Inhibition of PTEN Aggravates Acute Kidney Injury. Sci Rep. 2017 Aug 25; 7(1): 9503.
[7]. Kim MS, et, al. Nanotherapeutics of PTEN Inhibitor with Mesoporous Silica Nanocarrier Effective for Axonal Outgrowth of Adult Neurons. ACS Appl Mater Interfaces. 2016 Jul 27; 8(29): 18741-53.