Spironolactone (SC9420) 是一种具有口服活性的醛固酮盐皮质激素受体拮抗剂 | MedChemExpress (MCE)

中文名：螺内酯

CAS：52-01-7

品牌：MedChemExpress (MCE)

存储条件：Powder: -20°C, 3 years; 4°C, 2 years.In solvent: -80°C, 6 months; -20°C, 1 month.

生物活性：Spironolactone (SC9420) 是一种具有口服活性的醛固酮盐皮质激素受体拮抗剂，IC50 为 24 nM。 Spironolactone 也是一种有效的雄激素受体拮抗剂，IC50 为 77 nM。螺内酯促进足细胞[1][2][3]中的自噬。

参考详情：Spironolactone (SC9420，螺内酯) - 仅供科研 | Mineralocorticoid Receptor/Androgen Receptor Antagonist | MCE

 

参考文献：

[1]. Kim GK, et al. Oral Spironolactone in Post-teenage Female Patients with Acne Vulgaris: Practical Considerations for the Clinician Based on Current Data and Clinical Experience. J Clin Aesthet Dermatol. 2012;5(3):37-50.

[2]. Fagart J, et al. A new mode of mineralocorticoid receptor antagonism by a potent and selective nonsteroidal molecule. J Biol Chem. 2010;285(39):29932-29940.

[3]. Dong D, et al. Spironolactone alleviates diabetic nephropathy through promoting autophagy in podocytes. Int Urol Nephrol. 2019;51(4):755-764.