Isosilybin A 是一种从水飞蓟素中分离出来的黄酮木脂素 |MedChemExpress (MCE)

中文名：异水飞蓟宾A

CAS：142796-21-2

品牌：MedChemExpress (MCE)

存储条件：Powder: -20°C, 3 years; 4°C, 2 years.In solvent: -80°C, 6 months; -20°C, 1 month.

生物活性：Isosilybin A 是一种从水飞蓟素中分离出来的黄酮木脂素，具有抗前列腺癌 (PCA) 活性。异水飞蓟宾 A 抑制癌细胞增殖并诱导 G1 期阻滞和细胞凋亡，通过靶向Akt-NF-κB-雄激素受体 (AR) 轴激活 PCA 细胞的凋亡机制[1][2]。

 参考详情：Isosilybin A (异水飞蓟宾A) - 仅供科研 | Apoptosi Activator | MCE

参考文献：

[1]. Deep G, et al. Isosilybin B and isosilybin A inhibit growth, induce G1 arrest and cause apoptosis in human prostatecancer LNCaP and 22Rv1 cells. Carcinogenesis. 2007 Jul;28(7):1533-42.

[2]. Deep G, et al. Isosilybin A induces apoptosis in human prostate cancer cells via targeting Akt, NF-κB, and androgen receptor signaling. Mol Carcinog. 2010 Oct;49(10):902-12.