中文名:阿立哌唑
CAS:129722-12-9
品牌:MedChemExpress (MCE)
存储条件:4°C, protect from light
生物活性:Aripiprazole (OPC-14597) 是一种非典型抗精神病药,是一种有效且高亲和力的 dopamine D2 receptor 部分激动剂。 Aripiprazole 是 5-HT2B 和 5-HT2A 受体的反向激动剂,对 5-HT1A、5- HT2C、D3 和 D4 受体。阿立哌唑可用于精神分裂症和COVID19的研究[1][2][3][4]。
体外:阿立哌唑有效激活 D2 受体介导的 cAMP 积累抑制[1]。
阿立哌唑对 TNF-α、IL-13、IL-17α 和 fractalkine 显示出更强的抗炎作用[3]。
体内:Aripiprazole(0-3 mg/kg,IP,每日)表现出一定的抗焦虑特性[4]。
参考详情:Aripiprazole (OPC-14597,阿立哌唑) - 仅供科研 | D2/5-HT1A激动剂 | MCE
参考文献:
[1]. Stip E, et al. Aripiprazole in schizophrenia and schizoaffective disorder: A review. Clin Ther. 2010;32 Suppl 1:S3-20.
[2]. Burris KD, et al. Aripiprazole, a novel antipsychotic, is a high-affinity partial agonist at human dopamine D2 receptors. J Pharmacol Exp Ther. 2002 Jul;302(1):381-9.
[3]. Davies MA, et al. Aripiprazole: a novel atypical antipsychotic drug with a uniquely robust pharmacology. CNS Drug Rev. 2004 Winter;10(4):317-36.
[4]. Crespo-Facorro B, et al. Aripiprazole as a Candidate Treatment of COVID-19 Identified Through Genomic Analysis. Front Pharmacol. 2021 Mar 2;12:646701.
[5]. Russo E, et al. Ameliorating effects of aripiprazole on cognitive functions and depressive-like behavior in a genetic rat model of absence epilepsy and mild-depression comorbidity. Neuropharmacology. 2013 Jan;64:371-9.