CAS:2097104-58-8
品牌:MedChemExpress (MCE)
存储条件:Please store the product under the recommended conditions in the Certificate of Analysis.
生物活性:Spesolimab (BI 655130) 是一种抗 IL-36R 抗体。IL-36 在免疫系统中具有重要作用,Spesolimab 可用于掌跖脓疱病 (PPP) 的研究。Spesolimab 与先天性、Th1/Th17 和中性粒细胞途径相关的生物标志物的减少有关。
参考详情:Spesolimab (BI 655130,佩索利单抗) - 仅供科研 | 抗IL-36R抗体 | MCE
参考文献:
[1]. Mrowietz U, et al. Spesolimab, an Anti-Interleukin-36 Receptor Antibody, in Patients with Palmoplantar Pustulosis: Results of a Phase IIa, Multicenter, Double-Blind, Randomized, Placebo-Controlled Pilot Study. Dermatol Ther (Heidelb). 2021 Apr;11(2):571-585.
[2]. Geller S, et al. CCR4 expression in CD8+ cutaneous T-cell lymphomas and lymphoproliferative disorders and its implications for diagnosis and treatment[C]//Journal of Investigative Dermatology. STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA: ELSEVIER SCIENCE INC, 2019, 139(9): B25-B25.