CAS:1339202-33-3 Diazo Biotin-PEG3-azide 重氮生物素-叠氮化物

Diazo Biotin-PEG3-azide

中文名称:重氮生物素-叠氮化物

英文名称:Diazo Biotin-PEG3-azide,Diazo Biotin-PEG3-N3

CAS:1339202-33-3

分子式:C33H45N9O7S

分子量:711.83

规格标准:1g,5g,10g,可提供mg级以及kg级的产品开发服务

固体/粉末

溶于大部分有机溶剂,溶于水

纯度标准95%+

保存建议:避免反复冻融,避光保存,储液应该立即使用,任何未用的溶液分装小份冷冻于 < -20°C

特点与应用
特点
高反应性:

重氮基团和叠氮基团均具有高反应性,特别适合于点击化学反应。
高亲和力:

生物素能够与亲和素(Avidin)或链霉亲和素(Streptavidin)高效结合,适用于生物标记和检测。
水溶性和生物相容性:

PEG链增加了分子的水溶性和生物相容性,减少了非特异性结合。

相关产品:

生物素-聚赖氨酸偶联物  Biotin-PLL  
生物素偶联的小鼠球蛋白 (Biotin-Globulin)
生物素化肝素 heparin-biotin
N,N’-二甲基-N-生物素酰-N’-(4’-亚甲基-4,5’,8-三甲基补骨脂素)-3,6-二氧-辛二胺(V)
生物素化泊洛沙姆Pluronic/聚乳酸嵌段共聚物   BIOTIN@Pluronic F127@PLA
生物素修饰四氨基卟啉  TAPPH2-biotin
生物素化氨基化  Fe3O4@Biotin
生物素化物酶(Bitinidase EC3,5,1,12)
QY小编zyl分享2024.6.21

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润色下面英文:The controlled drug delivery systems, due to their precise control of drug release in spatiotemporal level triggered by specific stimulating factors and advantages such as higher utilization ratio of drug, less side-effects to normal tissues and so forth, provide a new strategy for the precise treatment of many serious diseases, especially tumors. The materials that constitute the controlled drug delivery systems are called “smart materials” and they can respond to the stimuli of some internal (pH, redox, enzymes, etc.) or external (temperature, electrical/magnetic, ultrasonic and optical, etc.) environments. Before and after the response to the specific stimulus, the composition or conformational of smart materials will be changed, damaging the original balance of the delivery systems and releasing the drug from the delivery systems. Amongst them, the photo-controlled drug delivery systems, which display drug release controlled by light, demonstrated extensive potential applications, and received wide attention from researchers. In recent years, photo-controlled drug delivery systems based on different photo-responsive groups have been designed and developed for precise photo-controlled release of drugs. Herein, in this review, we introduced four photo-responsive groups including photocleavage groups, photoisomerization groups, photo-induced rearrangement groups and photocrosslinking groups, and their different photo-responsive mechanisms. Firstly, the photocleavage groups represented by O-nitrobenzyl are able to absorb the energy of the photons, inducing the cleavage of some specific covalent bonds. Secondly, azobenzenes, as a kind of photoisomerization groups, are able to convert reversibly between the apolar trans form and the polar cis form upon different light irradiation. Thirdly, 2-diazo-1,2-naphthoquinone as the representative of the photo-induced rearrangement groups will absorb specific photon energy, carrying out Wolff rearrangement reaction. Finally, coumarin is a promising category photocrosslinking groups that can undergo [2+2] cycloaddition reactions under light irradiation. The research progress of photo-controlled drug delivery systems based on different photo-responsive mechanisms were mainly reviewed. Additionally, the existing problems and the future research perspectives of photo-controlled drug delivery systems were proposed.
02-06

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