\documentclass[12pt]{article}
\usepackage{xeCJK}
\usepackage{fontspec}
\setCJKmainfont[AutoFakeBold=5,AutoFakeSlant=0.2]{SimSun}
% AutoFakeSlant在CTex套装中会出错,建议使用Texlive
\newcommand{\fontKai}{\fontspec[ExternalLocation=C:/Windows/Fonts/]{simkai.ttf}\selectfont}
\newcommand{\fontSong}{\fontspec[ExternalLocation=C:/Windows/Fonts/]{simsun.ttc}\selectfont}
\newcommand{\fontLi}{\fontspec[ExternalLocation=C:/Windows/Fonts/]{SIMLI.TTF}\selectfont}
\begin{document}
\textit{\textbf{\fontKai 使用Xelatex进行编译。}}{\fontKai 使用Xelatex进行编译。}
\end{document}