[Database] CPMCP: a database of Chinese patent medicine and compound prescription

最新推荐文章于 2024-10-17 18:58:27 发布

南开大学_生物大数据实验室

最新推荐文章于 2024-10-17 18:58:27 发布

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CPMCP是一个专注于中药复方的数据库，包含了中成药和古方的处方信息、成分、适应症和禁忌症。它独特地注解了复方与中医证候的关系，建立了与现代医学证候的联系，并总结了药物配伍原则，旨在推动中医药的现代化进程。

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CPMCP: a database of Chinese patent medicine and compound prescription

摘要

现有的中医药相关数据库，都主要聚焦于单一药材的属性，远远不能满足临床研究和应用的需要。相比之下，中医复方在中国传统医学中更具有临床价值。因为中医复方除了考虑相对孤立的单一药材外，还要考虑中药材间的配伍信息。药材的配伍机制在中医中是必不可少的，因为它不仅体现了治疗特殊疾病所涉及的成分，而且还对如何组合这些单一的药材进行了指导。
我们建立了中成药及复方制剂数据库(简称CPMCP)。展示了中成药(CPMs)和中医古方(CMPs)的处方信息。CPMCP报告了它们全面和标准化的信息，如成分、适应症和禁忌症。值得一提的是，我们组织了相关专家，花了大量时间人工注释了由古汉语所标注的复方的功能与中医标准证候词汇间的对应关系，得到复方与中医证候的关联关系共计71414个。由此，CPMCP根据中医证候与现代医学（MM）证候的关联关系，建立了中药与MM证候的关联关系。此外，为了进一步展示复方处方配伍机制，CPMCP通过对现有处方的分析，总结出了一套常用的药物配伍原则。我们相信，CPMCP能够推动中医药现代化，为中医药发展做出更大贡献。

Abstract

Though several Traditional Chinese Medicine (TCM)-related databases have emerged, they focus on researching single medicinal materials, which is far from sufficient for clinical research and application. In comparison, compound prescriptions are more informative and meaningful in TCM, for they embody the information on the compatibility of TCM besides the relatively isolated information about single medicinal materials. The compatibility information is essential in TCM because it conveys not only what components are involved to treat special diseases but also how to combine these single medical materials. We established a database of Chinese Patent Medicine and Compound Prescription (CPMCP in short). It demonstrates the prescription information of Chinese Patent Medicines (CPMs) and ancient Chinese Medicine Prescriptions (CMPs). CPMCP reports their comprehensive and standardized information such as the components, indications, and contraindications. It is worth mentioning that we organized relevant experts and spent lots of time manually mapping the functions of compound prescriptions in ancient Chinese to the standardized TCM symptom vocabularies, obtaining a total of 71,414 associations between compound prescriptions and TCM symptoms. In this way, CPMCP established the associations between TCM and Modern Medicine (MM) according to the associations between TCM symptoms and MM symptoms. In addition, to further exhibit the compatibility mechanism of compound prescriptions, CPMCP summarizes a set of common drug combination principles by analyzing the existing prescriptions. We believe that CPMCP can promote the modernization of TCM and make greater contributions to MM.

论文地址：https://doi.org/10.1093/database/baac073

网站地址：http://cpmcp.top

CPMCP网站示意图

图1 CPMCP网站示意图

CPMCP展示了中成药 (CPM) 和传统中医古方 (CMP) 的成分信息、适应症和禁忌症等全面和标准化的信息（如图2所示）。并通过分析现有方剂，总结出了一套常用的配伍原则（如图3所示）。

在这里插入图片描述

图2 CPMCP所包含的信息。黄色的文本框和线条表示 CPMCP 与其他中药相关数据库相比的新功能。 (a) CPMCP 中实体之间的关系。 (b) 实体所包含的详细信息。 (c) 举例说明如何构建中医复方的功能主治与中医症状词汇之间的关联。

在这里插入图片描述

图3 白芍的9种常见配伍

关于数据库的更多介绍请访问数据库官网（官网提供中英双语显示）。

[1] Chang Sun, Jipeng Huang, Rong Tang, Minglei Li, Haili Yuan, Yuxiang Wang, Jin-Mao Wei, Jian Liu, CPMCP: a database of Chinese patent medicine and compound prescription, Database, Volume 2022, 2022, baac073, https://doi.org/10.1093/database/baac073