http://www.telerik.com/help/aspnet-ajax/introduction-troubleshooting.html
Uncaught Error: ASP.NET Ajax client-side framework failed to load.
Uncaught ReferenceError: Sys is not defined
Uncaught ReferenceError: Telerik is not defined
Change:
<add name="Telerik.Web.UI.WebResource.axd_*" path="Telerik.Web.UI.WebResource.axd" verb="*" type="Telerik.Web.UI.WebResource, Telerik.Web.UI" preCondition="integratedMode,runtimeVersionv2.0" />
To:
<remove name="Telerik_Web_UI_WebResource_axd"/>
<add name="Telerik_Web_UI_WebResource_axd" path="Telerik.Web.UI.WebResource.axd" type="Telerik.Web.UI.WebResource" verb="*" preCondition="integratedMode" />