use "OnCommand" event to handle multiple button click

 <form id="form1" runat="server">
    <div>
        <asp:Button ID="Button1" runat="server" Text="Button" CommandName="A"  OnCommand="CommandEventHandler" />
        <asp:Button ID="Button2" runat="server" Text="Button" CommandName="B" OnCommand="CommandEventHandler" />
        <asp:Button ID="Button3" runat="server" Text="Button" CommandName="C" OnCommand="CommandEventHandler" />
        <asp:Button ID="Button4" runat="server" Text="Button" CommandName="D" OnCommand="CommandEventHandler" />
        <asp:Button ID="Button5" runat="server" Text="Button" CommandName="E" OnCommand="CommandEventHandler" />
        <asp:Button ID="Button6" runat="server" Text="Button" CommandName="F" OnCommand="CommandEventHandler" />
    </div>
    </form>

 protected void CommandEventHandler(Object sender, CommandEventArgs e)
        {

            string s = e.CommandName;
        }