If you mean the screen where you have that interpreter prompt >>>
,
you can do CNTL-L
on Bash shell can help.
Windows does not have equivalent. You can do
import os
os.system('cls') #on windows
or
os.system('clear') # on linux / os x
reference:
http://stackoverflow.com/questions/4810537/how-to-clear-the-screen-in-python