using System.IO; using System.Runtime.InteropServices;[DllImport( " kernel32.dll " )] public static extern IntPtr _lopen( string lpPathName, int iReadWrite);[DllImport( " kernel32.dll " )] public static extern bool CloseHandle(IntPtr hObject); public const int OF_READWRITE = 2 ; public const int OF_SHARE_DENY_NONE = 0x40 ; public readonly IntPtr HFILE_ERROR = new IntPtr( - 1 ); private void button1_Click( object sender, EventArgs e) { string vFileName = @"c:\temp\temp.bmp"; if (!File.Exists(vFileName)) { MessageBox.Show("文件都不存在,你就不要拿来耍了"); return; } IntPtr vHandle = _lopen(vFileName, OF_READWRITE | OF_SHARE_DENY_NONE); if (vHandle == HFILE_ERROR) { MessageBox.Show("文件被占用!"); return; } CloseHandle(vHandle); MessageBox.Show("没有被占用!");} 转载于:https://www.cnblogs.com/clal/archive/2008/06/13/1219538.html