Recently I've had some problems with my system running out of memory. It took a while to discover what was going on, but I eventually determined that when I copied large amounts of data to my machine from a file share an equivalently large amount of memory was put into 'Standby'. Task Manager doesn't appear to show the Standby memory usage, but Resource Monitor does. At first I could only get the memory back by rebooting, but I eventually I discovered that the SysInternals guys had written a great utility to free the memory (link below).
Here is a brief blurb on Standby memory:
The Standby list contains unmodified pages that have been removed from process working sets, which effectively makes the Standby list a cache. If a process needs a page that is on the Standby list, the memory manager immediately returns the page to its working set.
All pages on the Standby