python database is locked_sqlite3.OperationalError: database is locked

[root@localhost sqlalchemy]# python manage.py db migrate

/root/py_env/coacs/lib/python3.6/site-packages/flask_sqlalchemy/__init__.py:794: FSADeprecationWarning: SQLALCHEMY_TRACK_MODIFICATIONS adds significant overhead and will be disabled by default in the future. Set it to True or False to suppress this warning.

'SQLALCHEMY_TRACK_MODIFICATIONS adds significant overhead and '

INFO [alembic.runtime.migration] Context impl SQLiteImpl.

INFO [alembic.runtime.migration] Will assume non-transactional DDL.

Traceback (most recent call last):

File "/root/py_env/coacs/lib/python3.6/site-packages/sqlalchemy/engine/base.py", line 1193, in _execute_context

context)

File "/root/py_env/coacs/lib/python3.6/site-packages/sqlalchemy/engine/default.py", line 508, in do_execute

cursor.execute(statement, parameters)

sqlite3.OperationalError: database is locked