镜像标准化（enantiomorphic normalization）：肿瘤和脑损伤患者标准化的一种方法

最开始笔者是想做一个语言网络附近肿瘤患者和皮质相厚度关性的研究，为此尝试了ANTs和freesurfer，发现freesurfer在处理有些肿瘤患者，跑了一两周也没有结束，可能陷入了局部最小值或者其它原因。我就在想有没有其它的方法。结果发现了这篇文章《Modeling Brain Dynamics in Brain Tumor Patients Using the Virtual Brain》。里面是为了用计算vertices构建的brain atlas：Glioma tumors, in contrast, generally do infiltrate the brain. To obtain a whole-brain parcellation scheme for these patients, two additional steps were conducted. First, glioma tumors were segmented using the Unified Segmentation with Lesion toolbox (https://github.com/ CyclotronResearchCentre/USwithLesion, unpublished obser- vations). Second, the Normalisation tool of the BCBtoolkit (Foulon et al., 2018) was used to produce an enantiomorphic filling of the affected area by symmetrically filling up the lesion mask with healthy tissue of the contralateral hemisphere (Nachev et al., 2008). These normalized anatomic MRI data were then processed using the standard recon-all FreeSurfer processing pipeline. Resulting pa