list1 = [1, 2, 3, 4, 5, 6] list2 = [1, 3, 4, 5] 第一种 list3 = [item for item in list1 if item not in set(list2)] print(list3) # [2, 6] 第二种 print(set(list1) - set(list2)) # {2, 6}