近红外荧光染料IRDye 800CW 2-DG/BoneTag/EGF/RGD Optical Probe光学探头

IRDye 800CW 2-DG Optical Probe

IRDye 800CW 2-DG 光学探头

IRDye 800CW 2-DG（2-脱氧葡萄糖）是一种荧光光学成像剂，已被证明与来自许多细胞系（包括 A431、SW620、3T3-L1 和 PC3LMN4）的植入肿瘤发生反应。 这种光学显像剂已用于许多应用，包括与肿瘤生物学、肿瘤转移、糖尿病和关节炎有关的研究。

癌细胞通常以高代谢率为特征，例如糖酵解率升高。 该观察结果构成了使用葡萄糖类似物（例如 18F-2-脱氧-D-葡萄糖 (18FDG)）可视化原发性肿瘤及其转移的正电子发射断层扫描 (PET) 的基础。 放射性标记的 2-脱氧-D-葡萄糖 (2-DG) 通常不适用于癌症生物学的小动物研究。 已使用荧光团标记的 2-脱氧-D-葡萄糖变体，并取得了不同程度的成功。

IRDye 800CW 2-DG (2-deoxyglucose) is a fluorescent optical imaging agent that has been shown to be reactive with implanted tumors derived from many cell lines including A431, SW620, 3T3-L1, and PC3LMN4. This optical imaging agent has been used for numerous applications, including research pertaining to tumor biology, tumor metastases, diabetes, and arthritis.

Cancer cells are often characterized by a high metabolic rate exemplified by an elevated rate of glycolysis. This observation forms the basis for positron emission tomography (PET) using glucose analogues such as 18F-2-deoxy-D-glucose (18FDG) to visualize primary tumors and their metastasis. Radiolabeled 2-deoxy-D-glucose (2-DG) is generally impractical for use in small animal studies of cancer biology. Fluorophore-labeled variants of 2-deoxy-D-glucose have been used with varying degrees of success.

IRDye 800CW BoneTag™ Optical Probe

IRDye 800CW BoneTag™ 光学探头

IRDye 800CW BoneTag 光学探针是一种与 IRDye 800CW 近红外染料结合的钙螯合化合物。 使用 IRDye NIR 染料将荧光信号检测扩展到光谱的近红外荧光区域，而不会影响化合物作为矿化过程标记的能力。 NIR 荧光检测由于组织自发荧光低而提高了穿透深度，从而转化为低背景干扰。

IRDye 800CW BoneTag Optical Probe is a calcium-chelating compound conjugated to IRDye 800CW near-infrared dye. Using IRDye NIR dyes extends fluorescence signal detection to the near-infrared fluorescent region of the spectrum without affecting the compound’s ability to function as a marker of the mineralization process. NIR fluorescence detection improves depth of penetration due to low tissue autofluorescence, translating to low background interference.

 

 

钙螯合化合物已被有效地用于检测骨矿化、生长和形态变化，包括四环素衍生物、二甲酚橙、茜素、钙黄绿素和荧光素。 NIR 标记的帕米膦酸盐也已成功用于检测非侵入性光学成像中的动脉钙化。

Calcium-chelating compounds have been used effectively for the detection of bone mineralization, growth, and morphological changes, including tetracycline derivatives, xylenol orange, alizarin, calcein, and fluorescein. NIR-labeled pamidronate has also been successfully used for detection of arterial calcification in non-invasive optical imaging.

IRDye 800CW EGF Optical Probe

IRDye 800CW EGF 光学探头

IRDye 800CW EGF 光学探针是一种近红外 (NIR) 荧光标记的重组人表皮生长因子 (EGF)。 这种光学显像剂由与 LI-COR IRDye 800CW 红外染料偶联的含有 54 个氨基酸残基（分子量 = 6.2 kDa）的重组 EGF 多肽组成。

IRDye 800CW EGF Optical Probe is a near-infrared (NIR) fluorescently-labeled recombinant human epidermal growth factor (EGF). This optical imaging agent is composed of a recombinant EGF polypeptide containing 54 amino acid residues (molecular weight = 6.2 kDa) conjugated to the LI-COR IRDye 800CW infrared dye.

 

 

IRDye 800CW EGF 提供了一种多功能探针，可用于体外和体内测定，以及整个器官和组织切片分析。 已证明 EGF 结合的体内测定可有效监测表现出 EGFR 过表达的特定实体瘤模型。

IRDye 800CW EGF provides a versatile probe that can be used for in vitro and in vivo assays, as well as whole organ and tissue section analysis. In vivo assays of EGF binding have proven effective in monitoring specific solid tumor models that exhibit overexpression of EGFR.

IRDye 800CW RGD Optical Probe

 

 

IRDye 800CW RGD 光学探头

IRDye 800CW RGD 光学探头是一种 BrightSite™ 近红外 (NIR) 荧光标记的 RGD 显像剂，专门设计用于靶向肿瘤上整合素的过度表达。

整联蛋白是细胞表面异二聚体糖蛋白，参与细胞与细胞和细胞与基质的相互作用。 IRDye 800CW RGD 光学探针由识别基序 RGD (Arg-Gly-Asp) 组成，这是一个三肽序列，用于结合包括 αvβ3 在内的整联蛋白受体。 该受体类别涉及肿瘤生长、肿瘤侵袭性、转移、肿瘤诱导的血管生成、炎症、骨质疏松症和类风湿性关节炎。

IRDye 800CW RGD Optical Probe is a BrightSite™ near-infrared (NIR) fluorescently-labeled RGD imaging agent specifically designed to target the overexpression of integrins on tumors.

Integrins are cell surface heterodimeric glycoproteins involved in cell-to-cell and cell-to-matrix interactions. IRDye 800CW RGD Optical Probe is composed of the recognition motif, RGD (Arg-Gly-Asp), a tripeptide sequence used to bind integrin receptors including αvβ3. This receptor class is involved in tumor growth, tumor invasiveness, metastasis, tumor induced angiogenesis, inflammation, osteoporosis, and rheumatoid arthritis.

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IRDye荧光标记核酸组蛋白/核仁蛋白Nucleohistone
IRDye荧光标记乳白蛋白lactalbumin
IRDye荧光标记脂多糖Lipopolysaccharides
IRDye荧光标记凝集素Lectins
IRDye荧光标记乳铁蛋白Lactoferrin
IRDye荧光标记偶氮酪蛋白Azo-Casein
IRDye荧光标记层粘蛋白Laminin
IRDye荧光标记天青角蛋白Keratinazure
IRDye荧光标记鱼精蛋白Protamine
IRDye荧光标记铁氧还蛋白Ferredoxin
IRDye荧光标记绿色荧光蛋白Greenfluorescentprotein(GFP)
IRDye荧光标记抑肽酶蛋白AprotininProtein
IRDye荧光标记牛纤连蛋白FibronectinBovine
IRDye荧光标记凝血酶Thrombin
IRDye荧光标记巨球蛋白Macroglobulin
IRDye荧光标记胎蛋白Fetoprotein
IRDye荧光标记人微球蛋白MicroglobulinAlpha-1ProteinHuman
IRDye荧光标记血管稳定因子Angiostatin
IRDye荧光标记肌集钙蛋白/隐钙素Calsequestrin
IRDye荧光标记环孢霉素Cyclosporin-A
IRDye荧光标记章鱼唾腺精Eledoisin
IRDye荧光标记恩夫韦地Enfuvirtide
IRDye荧光标记细丝蛋白Filamin
本文由QiyueLh整理，2022年6月7日