LL-37, Human | 154947-66-7 | 高品质抗菌肽系列

Host defense peptides (often called cationic antimicrobial peptides) have pleiotropic immunomodulatory functions. The human host defense peptide LL-37 is up-regulated at sites of infection and has little or no antimicrobial activity in tissue-culture media but under the same conditions, demonstrates immunomodulatory effects on epithelial cells, monocytes, and dendritic cells (DC). These effects include the induction of chemokine production in a mitogen-activated protein kinase-dependent manner in epithelial cell lines and monocytes and profound alterations of DC differentiation, resulting in the capacity to enhance a T helper cell type 1 response. 

宿主防御肽（通常称为阳离子抗菌肽）具有多效性免疫调节功能。人宿主防御肽LL-37在感染部位上调，在组织培养基中几乎没有或没有抗菌活性，但在相同条件下，显示出对上皮细胞、单核细胞和树突状细胞（DC）的免疫调节作用。这些作用包括在上皮细胞系和单核细胞中以促分裂原活化蛋白激酶依赖的方式诱导趋化因子的产生，以及DC分化的深刻改变，从而增强T辅助细胞1型反应的能力。

别名：CAP-18;antibacterial peptide LL-37;Cathelicidin LL-37; LL 37; Peptide LL 37 (human gene FALL39 antibacterial)
纯度：>95% 或 >98%
序列：LLGDFFRKSKEKIGKEFKRIVQRIKDFLRNLVPRTES
序列（三字母）：Leu-Leu-Gly-Asp-Phe-Phe-Arg-Lys-Ser-Lys-Glu-Lys-Ile-Gly-Lys-Glu-Phe-Lys-Arg-Ile-Val-Gln-Arg-Ile-Lys-Asp-Phe-Leu-Arg-Asn-Leu-Val-Pro-Arg-Thr-Glu-Ser
CAS No.: 154947-66-7
分子式：C205H340N60O53
分子量：4493.33
外观：白色粉末

Scrambled-Beta-Amyloid (1-42)序列分析：

引用文献：

 

1，Impact of LL-37 on anti-infective immunity
Dawn M E Bowdish,   Donald J Davidson,   Y Elaine Lau,   Ken Lee, Monisha G Scott, Robert E W Hancock
Journal of Leukocyte Biology, Volume 77, Issue 4, Apr 2005, Pages 451–459

2，Antibacterial Activity on Orthopedic Clinical Isolates and Cytotoxicity of the Antimicrobial Peptide Dadapin-1
Davide Campoccia, Lucio Montanaro, Stefano Ravaioli, Valentina Mariani, Giulia Bottau, Andrea De Donno and Carla Renata Arciola
Int. J. Mol. Sci. 2023, 24(1), 779

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