This happens because MySQL Administrator cannot find the location of your My.ini file. To correct this, go to Control Panel->Administrative Tools->Services and check the Properties entry (right-mouse click) against MySQL.
改为如下
"C:/mysql/bin/mysqld.exe" --defaults-file="C:/WINDOWS/MY.INI" MySQL
修改的方法是通过注册表:
HKEY_LOCAL_MACHINE/System/CurrentControlSet/Services/MySQL/ImagePath
You need to modify the key to read as above, including the quotes.
Stop and restart the MySQL service, and MySQL Administrator should then work correctly.
出处:http://forums.mysql.com/read.php?34,128259,128297#msg-128297