蛋白质硝基化修饰位点预测工具 —— GPS-YNO2 1.0

最新推荐文章于 2021-02-03 13:01:05 发布

casularm

最新推荐文章于 2021-02-03 13:01:05 发布

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分类专栏： 01.Publications 文章标签：工具 validation function system structure performance

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GPS-YNO2 1.0是一款用于预测蛋白质硝基化位点的工具，基于手动收集的实验验证数据进行开发。该算法通过多种交叉验证评估，表现出良好的预测性能，准确度达到76.51%，敏感度50.09%，特异性80.18%。此工具已实现在线服务和独立软件包，可供免费使用。

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Zexian Liu , Jun Cao, Qian Ma, Xinjiao Gao, Jian Ren and Yu Xue . (2010) GPS-YNO2: Computational prediction of tyrosine nitration sites in proteins. Molecular BioSystems (In press).

Early after the discovery of the freely-diffusible signaling molecule and second messenger nitric oxide (NO) and its function in signal transduction within the vasculature and nervous system, it became obvious that NO also take part in cytotoxic cytotoxicity when abundantly produced by iNOS, eNOS or nNOS (Ignarro, L.J. et al ., 1990 ). When NO meets molecular oxygen in hydrophobic environments where these species concentrate, the nitrogen dioxide could be formed, then reactive nitrogen species are derived which leave nitration as the molecular footprints by reactions with proteins. Tyrosine nitration is a kind of covalent post-translational modifications which adds a nitro (-NO2) group onto either one of the two ortho carbons of the aromatic ring of tyrosine resides. Originally, protein tyrosine nitration was considered to take place only in vitro mediated by reactive nitrating agent such as tetranitromethane (

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