CYP酶分类及功能简介

Family	Members	Subfamily (genes)	Main function
CYP1	3 subfamilies, 3 genes1 pseudogene	A (CYP1A1, CYP1A2), B (CYP1B1)	Xenobiotic and steroid (including estrogen) metabolism
CYP2	13 subfamilies, 16 genes 16 pseudogenes	A (CYP2A6, CYP2A7, CYP2A13), B (CYP2B6), C (CYP2C8, CYP2C9, CYP2C18, CYP2C19), D (CYP2D6), E (CYP2E1), F (CYP2F1), J (CYP2J2), R (CYP2R1), S (CYP2S1), U (CYP2U1), W (CYP2W1)	Xenobiotic and steroid metabolism
CYP3	1 subfamiliy, 4 genes 2 pseudogenes	A (CYP3A4, CYP3A5, CYP3A7, CYP3A43)	Xenobiotic and steroid (including testosterone) metabolism
CYP4	6 subfamilies, 12 genes 10 pseudogenes	A (CYP4A11, CYP4A22), B (CYP4B1), F (CYP4F2, CYP4F3, CYP4F8, CYP4F11, CYP4F12, CYP4F22), V (CYP4V2), X (CYP4X1), Z (CYP4Z1)	Fatty acid, arachidonic acid, and leukotriene metabolism
CYP5	1 subfamiliy, 1 gene	A (CYP5A1)	Thromboxane A2 synthesis
CYP7	2 subfamilies, 2 genes	A (CYP7A1), B (CYP7B1)	Bile acid synthesis
CYP8	2 subfamilies, 2 genes	A (CYP8A1), B (CYP8B1)	Prostacyclin syntehsis, bile acid syntehsis
CYP11	2 subfamilies, 3 genes	A (CYP11A1), B (CYP11B1, CYP11B2)	Steroid synthesis
CYP17	1 subfamiliy, 1 gene	A (CYP17A1), B (CYP17B1)	Steroid synthesis
CYP19	1 subfamiliy, 1 gene	A (CYP19A1)	Steroid synthesis
CYP20	1 subfamiliy, 1 gene	A (CYP20A1)	Unknown
CYP21	2 subfamilies, 1 gene 1 pseudogene	A (CYP21A2)	Steroid synthesis
CYP24	1 subfamiliy, 1 gene	A (CYP24A1)	Vitamin D metabolism
CYP26	3 subfamilies, 3 genes	A (CYP26A1), B (CYP26B1), C (CYP26C1)	Vitamin A metabolism
CYP27	3 subfamilies, 3 genes	A (CYP27A1), B (CYP27B1), C (CYP27C1)	Vitamin D and bile acid synthesis
CYP39	1 subfamiliy, 1 gene	A (CYP39A1)	Bile acid synthesis
CYP46	1 subfamiliy, 1 gene	A (CYP46A1)	Cholesterol synthesis
CYP51	1 subfamiliy, 1 gene	A (CYP51A1)	Cholesterol synthesis

CYP酶在PUFAs中的作用-哺乳动物长链 n-6 和 n-3 多不饱和脂肪酸 （PUFA） 的生物合成途径。

花生四烯酸（AA）的生物活化。生理活性AA代谢物的产生由环氧合酶（COX），脂氧合酶（LOX）和细胞色素P450（CYP）酶启动。

n-6多不饱和脂肪酸的细胞色素P450（CYP）依赖性代谢。所描述的结构式是各个CYP亚型以区域和立体选择性方式产生的各种环氧和羟基代谢物的例子。环氧代谢物通过可溶性环氧化物水解酶（sEH）水解为相应的邻二醇

细胞色素 P450 （CYP） 依赖性 n−3 多不饱和脂肪酸的代谢。与它们的n-6对应物类似，n-3多不饱和脂肪酸主要通过羟基化和环氧化代谢，如所选代谢物的结构式所示。如文中详细描述，ω-3 双键为许多不同的 CYP 亚型提供了首选的环氧化位点。环氧代谢物通过可溶性环氧化物水解酶（sEH）水解为相应的邻二醇。

参考文献

Song YS, Annalora AJ, Marcus CB, Jefcoate CR, Sorenson CM, Sheibani N. Cytochrome P450 1B1: A Key Regulator of Ocular Iron Homeostasis and Oxidative Stress. Cells. 2022 Sep 20;11(19):2930. doi: 10.3390/cells11192930IF: 6.0 Q2 . PMID: 36230892; PMCID: PMC9563809.

Konkel A, Schunck WH. Role of cytochrome P450 enzymes in the bioactivation of polyunsaturated fatty acids. Biochim Biophys Acta. 2011 Jan;1814(1):210-22. doi: 10.1016/j.bbapap.2010.09.009. Epub 2010 Sep 30. PMID: 20869469.