Estradiol benzoate | 苯甲酸雌二醇 _ MedChemExpress (MCE)

Estradiol benzoate | 苯甲酸雌二醇

MCE 国际站：Estradiol benzoate

中文名：苯甲酸雌二醇

CAS：50-50-0

品牌：MedChemExpress (MCE)

存储条件：Powder: -20°C, 3 years; 4°C, 2 years.In solvent: -80°C, 6 months; -20°C, 1 month.

生物活性：Estradiol Benzoate (β-Estradiol 3-benzoate) 是雌二醇的前药，是一种类固醇性激素。它表现出温和的合成代谢和代谢特性，并增加血液凝固性[1][2][3]。

体外：Estradiol benzoate (5-75 μM, 24 h-48 h) 对 SBHX21 细胞中 HBV 的翻译、转录和复制有下调作用[3]。 Estradiol benzoate (0-500 μM, 72 h) 对人包皮成纤维细胞 (HFFs) 有毒性[4]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only.

体内：Estradiol benzoate (20-100 μg/kg, Subcutaneous injection, once a day for 4-5 weeks) 改善 Ovx 雌性小鼠的学习记忆行为[1]。 Estradiol benzoate (0.015-15000 μg/kg, Subcutaneous injection, single dose) 使雄性 SD 大鼠的青春期提前[2]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Ovx mice[1] Dosage: 20, 100 or 200 μg/kg Administration: Subcutaneous injection (s.c.) Result: Significantly reversed the lowered uterine weight induced by Ovx. Had no obvious effects on locomotor activity in Ovx mice. Effectively reversed the changes of enlarging the width of synaptic cleft and reducing the thickness of PSD induced by Ovx. Increased the number and density of synaptic vesicles by 4-week replacement with EB (100 μg/kg).

热销产品：Escitalopram (oxalate)  | Artemisitene  | Estradiol 3-sulfamate  | GDC-0623  | Aluminum Hydroxide  | Donepezil (Hydrochloride)  | 1,2-Dioleoyl-sn-glycero-3-phosphate, sodium salt  | Datopotamab  | ML216  | Mizoribine

研究领域：Vitamin D Related/Nuclear Receptor  |  Anti-infection  |  Apoptosis

作用靶点：Estrogen Receptor/ERR  |  HBV  |  Bcl-2 Family

Trending products：Recombinant Proteins  |  Bioactive Screening Libraries  |  Natural Products  |  Fluorescent Dye  |  PROTAC  |  Isotope-Labeled Compounds  |  Oligonucleotides

参考文献：

[1]. Zovko M, et al. Macromolecular prodrugs XI. Synthesis and characterization of polymer-estradiol conjugate. Int J Pharm. 2004 Nov 5;285(1-2):35-41.

[2]. García-Gómez E, et al. Role of sex steroid hormones in bacterial-host interactions. Biomed Res Int. 2013;2013:928290.

[3]. Estradiol benzoate

[4]. Xu X, et al. Effects of estradiol benzoate on learning-memory behavior and synaptic structure in ovariectomized mice [J]. Life sciences, 2006, 79(16): 1553-1560.

[5]. Putz O, et al. Neonatal low-and high-dose exposure to estradiol benzoate in the male rat: I. Effects on the prostate gland [J]. Biology of reproduction, 2001, 65(5): 1496-1505.

[6]. He J, et al. Identification of Estradiol Benzoate as an Inhibitor of HBx Using Inducible Stably Transfected HepG2 Cells Expressing HiBiT Tagged HBx [J]. Molecules, 2022, 27(15): 5000.

[7]. Lu D, et al. Investigation of Antiparasitic Activity of Two Marine Natural Products, Estradiol Benzoate, and Octyl Gallate, on Toxoplasma gondii In Vitro [J]. Frontiers in Pharmacology, 2022, 13: 841941.

[8]. Rao M V, et al. Effect of estradiol benzoate on reproductive organs and fertility in the male rat [J]. European Journal of Obstetrics & Gynecology and Reproductive Biology, 1983, 15(3): 189-198.