中文名:阿莫西林
CAS:26787-78-0
品牌:MedChemExpress (MCE)
存储条件:4°C, protect from light
生物活性:阿莫西林(Amoxycillin)是一种抗生素,具有良好的口服吸收和广谱抗菌活性。阿莫西林抑制细胞壁中多肽的生物合成,从而抑制细胞生长[1][2][3]。
体外:阿莫西林 (Amoxycillin)(1-100 µM;24 小时;L. acidophilus)以剂量依赖性方式减少活细胞并增加细胞壁破裂程度[1] .
体内:阿莫西林(Amoxycillin)(7 mg/kg;ih;雌性 ICR/瑞士小鼠)在 1 mg/L 或更少时抑制品系数量并提高大鼠的存活率[2]。
阿莫西林 (Amoxycillin) (1.6-9.5 mg/kg; po; daily, for 7 or 14 days; swiss albino mice) 在小鼠中具有抗沙眼衣原体感染的作用[3]。
参考详情:Amoxicillin (Amoxycillin,阿莫西林) - 仅供科研 | 抗生素 | MCE
参考文献:
[1]. Geddes AM, et al. Introduction: historical perspective and development of amoxicillin/clavulanate. Int J Antimicrob Agents. 2007 Dec;30 Suppl 2:S109-12.
[2]. Handsfield HH,et al. Amoxicillin, a new penicillin antibiotic. Antimicrob Agents Chemother. 1973 Feb;3(2):262-5.
[3]. Guo Y, et, al. Metabolic response of Lactobacillus acidophilus exposed to amoxicillin. J Antibiot (Tokyo). 2022 May;75(5):268-281.
[4]. Andes D, et, al. In vivo activities of amoxicillin and amoxicillin-clavulanate against Streptococcus pneumoniae: application to breakpoint determinations. Antimicrob Agents Chemother. 1998 Sep;42(9):2375-9.
[5]. Kramer MJ, et, al. Activity of oral amoxicillin, ampicillin, and oxytetracycline against infection with chlamydia trachomatis in mice. J Infect Dis. 1979 Jun;139(6):717-9.