中文名:甲磺酸瑞波西汀
CAS:98769-84-7
品牌:MedChemExpress (MCE)
存储条件:4°C, sealed storage, away from moisture
生物活性:Reboxetine mesylate (FCE20124 mesylate) 是一种有效、选择性和特异性的去甲肾上腺素再摄取抑制剂 (NARI),用于抑郁症的研究。 Reboxetine mesylate 抑制去甲肾上腺素的摄取,Ki 为 8 nM[1]。 IC50 和目标:Ki:8 nM(NA 再摄取)[1]
体内: 甲磺酸瑞波西汀(30 mg/kg; ip) 显着减少小鼠抑郁模型的不动时间[1]。
体外:甲磺酸瑞波西汀对毒蕈碱、组胺能 H1、肾上腺素能 α1 和多巴胺能 D2 受体的亲和力较弱[1].
甲磺酸瑞波西汀可防止地塞米松诱导的细胞活力和增殖率降低[3].
体内:Reboxetine mesylate (30 mg/kg; ip) 显着减少小鼠抑郁模型的不动时间[1]。
参考详情:Reboxetine mesylate (FCE20124 mesylate,甲磺酸瑞波西汀) - 仅供科研 | NARI | MCE
参考文献:
[1]. Wong, E.H., et al., Reboxetine: a pharmacologically potent, selective, and specific norepinephrine reuptake inhibitor. Biol Psychiatry, 2000. 47(9): p. 818-29.
[2]. Versiani, M., et al., Reboxetine, a unique selective NRI, prevents relapse and recurrence in long-term treatment of major depressive disorder. J Clin Psychiatry, 1999. 60(6): p. 400-6.
[3]. M Leskiewicz, et al. Antidepressants attenuate the dexamethasone-induced decrease in viability and proliferation of human neuroblastoma SH-SY5Y cells: a involvement of extracellular regulated kinase (ERK1/2). Neurochem Int. 2013 Nov;63(5):354-62.