中文名:三氯生
CAS:3380-34-5
品牌:MedChemExpress (MCE)
存储条件:4°C, protect from light
生物活性:三氯生是一种抗菌剂和抗真菌剂,存在于消费品中,包括肥皂、洗涤剂、玩具和手术清洁剂。
体外:Triclosan (1-100 μM;24 小时) 在 50 和 100 μM 时,会以剂量和时间依赖性方式降低细胞活力。Triclosan 50 μM 浓度可显着增加裂解的 caspase3 和 Bax 蛋白并降低 Bcl-2[2]。 Triclosan (50 μM;1-3 小时) 会诱导磷酸化 p38 和 JNK 蛋白的表达增加[2]。 Triclosan (10-50 μM;3 小时) 在 50 μM 浓度会降低培养的 NSC 中的 GSH 活性,并将 ROS 生成量增加至约 40%[2]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only.
体内:Triclosan (5、50、500 mg/kg;口服灌胃,每周 5 天,共 4 周) 导致抗 Der f IgE、IL-4 和 IL-13 产生增加[ 3]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Wild type BALB/cJ mice[3] Dosage: 5, 50, 500 mg/kg Administration: Oral gavage, five days a week for a total of four weeks Result: Caused an increase in the production of anti- dermatophagoides farinae (Der f) IgE, IL‐4, and IL‐13, and this resulted in the aggravation of airway hyperresponsiveness in aeroallergen‐exposed wild type mice. Clinical Trial
参考详情:www.medchemexpress.cn/Triclosan.html
参考文献:
[1]. R J Heath, et al. Mechanism of triclosan inhibition of bacterial fatty acid synthesis. J Biol Chem. 1999 Apr 16;274(16):11110-4.
[2]. Bo Kyung Park, et al. Effects of Triclosan on Neural Stem Cell Viability and Survival. Biomol Ther (Seoul). 2016 Jan;24(1):99-107.
[3]. Jianan Zhang, et al. Microbial enzymes induce colitis by reactivating triclosan in the mouse gastrointestinal tract. Nat Commun. 2022 Jan 10;13(1):136.