Use mutex in wpf

    public class EntryPoint
    {
        [STAThread]
        public static void Main(string[] args)
        {
            SingleInstanceManager manager = new SingleInstanceManager();
            manager.Run(args);
        }
    }

    public class SingleInstanceManager : WindowsFormsApplicationBase
    {
        YourApp app;

        public SingleInstanceManager()
        {
            this.IsSingleInstance = true;
        }

        protected override bool OnStartup(Microsoft.VisualBasic.ApplicationServices.StartupEventArgs e)
        {
            app = new YourApp();
            app.Run();
            return false;
        }

        protected override void OnStartupNextInstance(StartupNextInstanceEventArgs eventArgs)
        {
            base.OnStartupNextInstance(eventArgs);
            app.Activate();
        }
    }

    public class YourApp : Application
    {
    }