<WebLogicServer> <BEA-000386> <Server subsystem failed. Reason: java.lang.NullPointerException

Solution:

When you see above error, please check
1. if the disk space is full
2. if disk space is fine, then delete the following file
/servers/AdminServer/data/ldap/conf/replicas.prop

and restart the server. WLS sometimes corrupts the file replicas.prop and is often results in above error

If still not work, then restart the myeclipse and clean the project.