《Nature》隶属于英国自然出版集团，涵盖自然科学全领域，并设有专门的生命科学板块；其强调跨学科融合，生物学内容常与化学、物理等学科交叉。
Volume 639 Issue 8053, 6 March 2025
www.nature.com/nature/volumes/639/issues/8053
Editorial（社论）
Trump 2.0: an assault on science anywhere is an assault on science everywhere
《特朗普2.0版：对科学的攻击无处不在》
A brain drain would impoverish the United States and diminish world science
《人才流失将削弱美国并损害全球科学》
World View（全球视野）
We moved a conference halfway around the globe to avoid visa discrimination
《为避免签证歧视，我们将会议迁至地球另一端》
Superpowers want to control critical mineral supplies — local communities need a stronger say
《大国争夺关键矿产控制权—当地社区需更多话语权》
Research Highlights（研究亮点）
Lhasa′s rocks reveal an Australian birthplace
《拉萨岩石揭示其澳大利亚起源》
Our Galaxy’s central black hole puts on a fireworks show
《银河系中心黑洞上演“烟花秀”》
Just a smidgen of yellow-fever vaccine is enough
《微量黄热病疫苗即可有效》
Take me home, country toads
《“带我回家”：蔗蟾蜍的非凡导航能力》
News in Focus（焦点新闻）
Postdocs and PhD students hit hard by Trump’s crackdown on science
《特朗普打压科学重创博士后与博士生群体》
What sparked the COVID pandemic? Mounting evidence points to raccoon dogs
《新冠大流行溯源：更多证据指向貉》
Breast cancer is on the rise: data reveal drastic gap in survival rates
《乳腺癌发病率上升：生存率差异悬殊》
US pulls back from gold-standard scientific climate panel
《美国退出权威气候科学小组》
How a junk-food splurge can change your brain activity
《垃圾食品如何短暂改变大脑活动》
NIH turmoil sparks anxiety over future of its global grants
《NIH动荡引发全球科研资助担忧》
‘Slime’ keeps the brain safe ― and could guard against ageing
《“黏液”保护大脑并延缓衰老》
Iconic ocean-current system is safe from climate collapse ― for now
《标志性洋流系统暂免气候崩溃》
Features（专题）
How much energy will AI really consume? The good, the bad and the unknown
《AI的真实能耗：利弊与未知》
The science of shopping addiction: what makes people buy loads of stuff?
《购物成瘾的科学：人们为何疯狂消费？》
Books & Arts（书评与艺术）
Against the odds: 12 women who beat bias to succeed in science
《逆流而上：打破偏见的12位女科学家》
Stories of people, past, present and future: Books in brief
《过去、现在与未来的人物故事：科学书籍速览》
Opinion（观点）
Train clinical AI to reason like a team of doctors
《训练临床AI像医生团队一样推理》
Use your research to beat health inequities: four strategies from experts
《用研究破除健康不平等：专家四策》
AI hallucinations are a feature of LLM design, not a bug
《AI幻觉是LLM设计的特性而非缺陷》
AI must be taught concepts, not just patterns in raw data
《AI需学习概念而非仅数据模式》
Elon Musk has some supporters in science
《科学界也有埃隆·马斯克的支持者》
Should scientists ditch the social-media platform X?
《科学家应弃用社交媒体平台X吗？》
Work（职场与工具）
Behind every great woman in science, there’s another great woman in science
《每位杰出女科学家背后都有另一位杰出女性》
ChatGPT for students: learners find creative new uses for chatbots
《学生用ChatGPT：生成式AI的创意新用途》
Tracking gulls to prevent a bird flu pandemic
《追踪海鸥以预防禽流感大流行》
Research（研究论文）
News & Views（新闻与观点）
Revealing how fungi build planet-altering ‘road’ networks
《真菌如何构建改变地球的“道路”网络》
Amazonian deforestation makes the wet season wetter, and the dry season drier
《亚马逊森林砍伐加剧雨季降水与旱季干旱》
Molecular glue unexpectedly mimics the effect of cancer mutations
《分子胶意外模拟癌症突变效应》
AI algorithm helps telescopes to pivot fast towards gravitational-wave sources
《AI算法助力望远镜快速锁定引力波源》
Could psychedelics be fine-tuned to relieve anxiety but skip the ‘trip’?
《能否定制迷幻药缓解焦虑而无幻觉？》
Genetic and geographical origins of Eurasia’s influential Yamna culture
《欧亚草原颜那文化的遗传与地理起源》
Articles（研究论文）
Real-time inference for binary neutron star mergers using machine learning
《机器学习实时推断双中子星合并》
Multiplexed entanglement of multi-emitter quantum network nodes
《多发射体量子网络节点的复用纠缠》
Spectroscopy of the fractal Hofstadter energy spectrum
《分形霍夫施塔特能谱的光谱学研究》
Interplay of geometrical and spin chiralities in 3D twisted magnetic ribbons
《三维扭曲磁带的几何与自旋手性互作》
Orbital hybridization in graphene-based artificial atoms
《石墨烯人工原子中的轨道杂化》
A single-fibre computer enables textile networks and distributed inference
《单纤维计算机实现织物网络与分布式推断》
Achieving kilowatt-scale elastocaloric cooling by a multi-cell architecture
《多单元架构实现千瓦级弹热冷却》
Steering perovskite precursor solutions for multijunction photovoltaics
《调控钙钛矿前驱体溶液助力多结光伏》
Impact of Amazonian deforestation on precipitation reverses between seasons
《亚马逊森林砍伐对降水的季节性逆转效应》
Glacial isostatic adjustment reveals Mars’s interior viscosity structure
《冰川均衡调整揭示火星内部黏度结构》
Contrasting drought sensitivity of Eurasian and North American grasslands
《欧亚与北美草原的干旱敏感性差异》
Maize monoculture supported pre-Columbian urbanism in southwestern Amazonia
《玉米单一栽培支撑前哥伦布时期亚马逊西南城市化》
A genomic history of the North Pontic Region from the Neolithic to the Bronze Age
《黑海北岸新石器时代至青铜时代的基因组史》
The genetic origin of the Indo-Europeans
《印欧语系人群的遗传起源》
Opponent control of reinforcement by striatal dopamine and serotonin
《纹状体多巴胺与血清素的拮抗强化控制》
Hippocampal neuronal activity is aligned with action plans
《海马神经元活动与行动计划一致》
Fine-tuning gibberellin improves rice alkali–thermal tolerance and yield
《精准调控赤霉素提升水稻耐碱热性与产量》
A travelling-wave strategy for plant–fungal trade
《植物-真菌交易的“行波”策略》
Limited impact of Salmonella stress and persisters on antibiotic clearance
《沙门氏菌应激与持留菌对抗生素清除影响有限》
Methanol transfer supports metabolic syntrophy between bacteria and archaea
《甲醇转移支持细菌与古菌的代谢互养》
SARS-CoV-2 evolution on a dynamic immune landscape
《动态免疫背景下的SARS-CoV-2进化》
Antibody prophylaxis may mask subclinical SIV infections in macaques
《抗体预防或掩盖猕猴亚临床SIV感染》
CD45-PET is a robust, non-invasive tool for imaging inflammation
《CD45-PET：炎症成像的稳健非侵入工具》
De novo designed proteins neutralize lethal snake venom toxins
《从头设计蛋白中和致命蛇毒毒素》
UM171 glues asymmetric CRL3–HDAC1/2 assembly to degrade CoREST corepressors
《UM171“分子胶”驱动CRL3–HDAC1/2组装降解CoREST辅阻遏物》
Converging mechanism of UM171 and KBTBD4 neomorphic cancer mutations
《UM171与KBTBD4新形态癌症突变的趋同机制》
美国华盛顿大学药理学系，等
功能性KBTBD4突变的结构机制和氨基酸偏好
Structural insights into RNA cleavage by PIWI Argonaute
《PIWI Argonaute切割RNA的结构机制》
Corrections（更正）
Author Correction: India–Eurasia convergence speed-up by passive-margin sediment subduction
《作者更正：被动边缘沉积俯冲加速印度-欧亚汇聚》
Author Correction: FANCD2–FANCI surveys DNA and recognizes double- to single-stranded junctions
《作者更正：FANCD2–FANCI监测DNA并识别双链-单链连接》
Author Correction: Fetal hepatocytes protect the HSPC genome via fetuin-A
《作者更正：胎肝细胞通过胎球蛋白A保护HSPC基因组》
Author Correction: Seasonal advance of intense tropical cyclones in a warming climate
《作者更正：气候变暖下强热带气旋的季节性提前》
Publisher Correction: Immune evasion through mitochondrial transfer in the tumour microenvironment
《出版方更正：肿瘤微环境中线粒体转移介导免疫逃逸》
Publisher Correction: Skin autonomous antibody production regulates host–microbiota interactions
《出版方更正：皮肤自主抗体生产调控宿主-微生物群互作》
Volume 639 Issue 8054, 13 March 2025
https://www.nature.com/nature/volumes/639/issues/8054
Editorial（社论）
Science diplomacy can help to heal global rifts — if research is respected
《科学外交可弥合全球裂痕—前提是尊重科研》
Why are proponents of ‘smart cities’ neglecting research?
《“智慧城市”倡导者为何忽视研究？》
World View（全球视野）
‘Silence is complicity’ — universities must fight the anti-DEI crackdown
《“沉默即共谋”—高校须反击反DEI浪潮》
“多元、公平与包容”（Diversity、Equity and Inclusion，简称DEI）。2025年，一些美国公司开始掀起“去DEI”的反觉醒浪潮，如丰田美国、沃尔玛、福特、Meta、麦当劳、莫尔森库尔斯酿酒、迪尔、Lowe's、亚马逊等，都与DEI分道扬镳。
Public-health experts should be more political, not less
《公共卫生专家应更深入政治，而非退缩》
Research Highlights（研究亮点）
Who’s likely to wake up from a coma? Brainwaves provide a clue
《脑电波预测昏迷患者苏醒可能性》
A super-gel stays supple from −115 ºC to 143 ºC
《超级凝胶在-115°C至143°C保持柔韧》
Ancient puppets that smile or scowl hint at shared rituals
《古代哭笑陶俑揭示共同仪式活动》
The surprising culprit for the loss of huge swathes of tropical forest
《热带森林消失的意外元凶：“次级”道路》
News in Focus（焦点新闻）
Exclusive: NIH to terminate hundreds of active research grants
《独家：NIH将终止数百项研究资助》
Trump’s nominee for NIH chief talks frozen grants and fostering ‘scientific dissent’
《特朗普提名的NIH负责人谈冻结资助与鼓励“科学异议”》
Meet the ‘woolly mouse’: why scientists doubt it’s a big step towards recreating mammoths
《“毛茸茸小鼠”：科学家质疑其复活猛犸象的意义》
China’s supreme court calls for crack down on paper mills
《中国最高法院要求打击论文工厂》
中国最高法院表示，为盈利而写虚假论文/手稿的企业应该受到惩罚。Top court says businesses that write bogus manuscripts for payment should be punished.
在中国，大量生产假冒出版物的论文"工厂"/"作坊"非常受欢迎，而且利润丰厚。In China, paper mills, which churn out fake publications, are very popular — and lucrative.
Why women’s brains are more resilient: it could be their ‘silent’ X chromosome
《女性大脑更具韧性：或源于“沉默”X染色体》
Private spacecraft nails Moon landing: first images of Blue Ghost on the lunar surface
《私人航天器精准登月：“蓝幽灵”着陆影像首公开》
‘Omg, did PubMed go dark?’ Blackout stokes fears about database’s future
《PubMed宕机引发数据库未来担忧》
Features（专题）
Alcohol and cancer risk: what you need to know
《酒精与癌症风险：你必须了解的事实》
Four ways COVID changed virology: lessons from the most sequenced virus of all time
《新冠如何改变病毒学：史上测序最多病毒的四大启示》
Books & Arts（书评与艺术）
The ‘quantum’ principle that says why atoms are as they are
《量子原理：原子为何如此存在？》
Rock hunters, tree huggers and taxi drivers: Books in brief
《岩石猎手、树抱族与出租车司机：科学书籍速览》
Opinion（观点）
Are microplastics bad for your health? More rigorous science is needed
《微塑料有害健康吗？需更严谨的科学验证》
How a vast digital twin of the Yangtze River could prevent flooding in China
《长江数字孪生如何助力中国防洪》
Similar chiral phenomena occur in cell cultures and human crowds
《细胞培养与人群中的手性现象相似性》
For more reliable AI, academics should edit Wikipedia
《提升AI可靠性：学者应参与编辑维基百科》
COP30 must deliver binding mechanisms to address climate change, not empty promises
《COP30需制定气候约束机制，而非空头承诺》
Fate of pistachio production in Iran holds lessons for the world
《伊朗开心果产业的命运为全球提供警示》
Work（职场与工具）
How blowing the whistle on the Theranos scandal transformed Erika Cheung’s career
《揭露Theranos丑闻如何改变黄艾琳的职业生涯》
I create buildings from mushroom components
《我用蘑菇材料建造房屋》
Research（研究论文）
News & Views（新闻与观点）
Genetic data from Indigenous Greenlanders could help to narrow health-care gap
《格陵兰原住民遗传数据缩小医疗差距》
Metals squeezed to thickness of just two atoms
《金属被压至两原子厚度》
Racial bias eliminated when ratings switch from five stars to thumbs up or down
《评分改为“赞/踩”可消除种族偏见》
An operating system for networked quantum computers is a huge practical step forward
《量子网络操作系统迈向实用化》
Peptides from abnormal RNA processing in cancer offer an immunotherapy target
《癌症异常RNA加工产生的多肽成免疫治疗靶点》
Perspective（观点研究）
A framework for neural organoids, assembloids and transplantation studies
《神经类器官、组装体与移植研究的框架》
Articles（研究论文）
An operating system for executing applications on quantum network nodes
《量子网络节点的应用执行操作系统》
Continuous-variable multipartite entanglement in an integrated microcomb
《集成微梳中的连续变量多体纠缠》
Emerging supersolidity in photonic-crystal polariton condensates
《光子晶体极化激元凝聚体中的超固态涌现》
Superconductivity and quantized anomalous Hall effect in rhombohedral graphene
《菱面体石墨烯的超导与量子反常霍尔效应》
Magnetically and optically active edges in phosphorene nanoribbons
《磷烯纳米带的磁光活性边缘》
Realization of 2D metals at the ångström thickness limit
《实现埃级厚度二维金属》
10,000-h-stable intermittent alkaline seawater electrolysis
《万小时稳定间歇性碱性海水电解》
Methane oxidation to ethanol by a molecular junction photocatalyst
《分子结光催化剂将甲烷氧化为乙醇》
Engineered enzymes for enantioselective nucleophilic aromatic substitutions
《工程化酶实现手性选择性亲核芳香取代》
Global biodiversity loss from outsourced deforestation
《外包式毁林导致全球生物多样性丧失》
Scale dichotomization reduces customer racial discrimination and income inequality
《评分二元化减少客户种族歧视与收入不平等》
Genetic architecture in Greenland is shaped by demography, structure and selection
《格陵兰遗传架构由人口、结构与选择塑造》
Massively parallel characterization of transcriptional regulatory elements
《转录调控元件的大规模并行表征》
Experience-dependent dopamine modulation of male aggression
《雄性攻击行为的经验依赖性多巴胺调控》
Activation and inhibition mechanisms of a plant helper NLR
《植物辅助NLR的激活与抑制机制》
Multi-interface licensing of protein import into a phage nucleus
《噬菌体核蛋白输入的多界面许可机制》
Tumour-wide RNA splicing aberrations generate actionable public neoantigens
《肿瘤RNA剪接异常产生可靶向公共新抗原》
A neoantigen vaccine generates antitumour immunity in renal cell carcinoma
《新抗原疫苗激发肾癌抗肿瘤免疫》
Transcriptional adaptation upregulates utrophin in Duchenne muscular dystrophy
《转录适应性上调了杜氏肌营养不良症中的肌营养不良蛋白》
德国马克斯·普朗克心肺研究所发育遗传学系，等
促进包含选择性剪接的含PTC外显子的引入，会引发DMD突变mRNA衰变和UTRN上调。PTC: 过早终止密码子；DMD: 杜兴氏肌肉萎缩症；UTRN: 肥厚因子
易生信-临床基因组学数据分析实战，5月开课
Engineered heart muscle allografts for heart repair in primates and humans
《工程化心肌同种异体移植物修复灵长类与人类心脏》
Engineering a genomically recoded organism with one stop codon
《基因组重编码生物：单终止密码子设计》
Targeting protein–ligand neosurfaces with a generalizable deep learning tool
《深度学习工具靶向蛋白-配体新表面》
Matters Arising（争议与回应）
Weather anomalies cannot explain insect decline
《天气异常无法解释昆虫减少》
Reply to: Weather anomalies cannot explain insect decline
《对“天气异常无法解释昆虫减少”的回应》
Corrections（更正）
Author Correction: The genetic origin of the Indo-Europeans
《作者更正：印欧语系人群的基因起源》
Author Correction: HIV-1 Env trimers asymmetrically engage CD4 receptors in membranes
《作者更正：HIV-1 Env三聚体非对称结合膜CD4受体》
Author Correction: The Ronne Ice Shelf survived the last interglacial
《作者更正：龙尼冰架挺过上一次间冰期》
Author Correction: A comprehensive spatio-cellular map of the human hypothalamus
《作者更正：人类下丘脑时空细胞图谱》
Author Correction: Neutralizing GDF-15 can overcome anti-PD-1 and anti-PD-L1 resistance in solid tumours
《作者更正：中和GDF-15可克服实体瘤抗PD-1/PD-L1耐药性》
Author Correction: CTLA4 blockade abrogates KEAP1/STK11-related resistance to PD-(L)1 inhibitors
《作者更正：CTLA4阻断消除KEAP1/STK11介导的PD-(L)1抑制剂耐药性》
Focal Point（焦点专题）
Focal Point on Ageing in Japan
《日本老龄化专题》
Volume 639 Issue 8055, 20 March 2025
https://www.nature.com/nature/volumes/639/issues/8055
Editorial（社论）
Cleaning up space: how satellites and telescopes can live together
《清理太空：卫星与望远镜如何共存》
Vaccines save lives. Leaders must champion them
《疫苗拯救生命—领导者必须捍卫疫苗》
World View（全球视野）
Governments must stop hoarding climate data
《各国政府必须停止囤积气候数据》
Don’t wait out four hard years: speak truth to power
《无需静待四年困局—向权力说出真相》
Research Highlights（研究亮点）
Mega-storm dumps 11 billion tonnes of snow ― and builds up a melting ice sheet
《超级风暴倾泻110亿吨雪—却减缓冰盖消融》
Bad romance: male octopuses inject deadly venom into their mates
《危险求偶：雄性蓝环章鱼向配偶注射致命毒液》
How extreme lethargy can promote healthy ageing
《极端嗜睡如何促进健康衰老》
Robotic fingers can tell objects apart by touch
《机器人手指通过触觉区分物体》
News in Focus（焦点新闻）
‘Scientists will not be silenced’: thousands protest Trump research cuts
《“科学家不会被禁言”：数千人抗议特朗普削减科研经费》
Move over graphene! Scientists forge bismuthene and host of atoms-thick metals
《石墨烯退散！科学家合成铋烯与其他原子级厚度金属》
How the NIH dominates the world’s health research — in charts
《图解NIH如何主导全球健康研究》
Microsoft quantum computing ‘breakthrough’ faces fresh challenge
《微软量子计算“突破”遭遇新质疑》
How a PhD student’s lab size affects their chance of future academic success
《博士生所在实验室规模如何影响其学术前景》
大型研究组的学员，在学术界的表现往往比小型组的学员好
How fast your brain ages is affected by these 64 genes
《64个基因影响大脑衰老速度》
NASA begins mass firings of scientists ahead of Trump team’s deadline
《NASA按特朗普团队要求启动科学家大规模裁员》
Features（专题）
The biggest machine in science: inside the fight to build the next giant particle collider
《科学界最大机器：下一代巨型粒子对撞机建设之争》
Swarms of satellites are harming astronomy. Here’s how researchers are fighting back
《卫星群危害天文学—科研人员如何反击》
Books & Arts（书评与艺术）
A radical manifesto for truth
《真理的激进宣言》
The untamed river and the Moog: Books in brief
《狂野河流与穆格合成器：科学书籍速览》
Opinion（观点）
Obituary（讣告）
Elisabeth Vrba obituary: palaeontologist who solved a problem that vexed Darwin
《伊丽莎白·弗尔巴讣告：破解达尔文难题的古生物学家》
Comment（评论）
Space debris is falling from the skies. We need to tackle this growing danger
《太空碎片从天而降—亟需应对日益增长的风险》
Why coalitions of wealthy nations should fund others to decarbonize
《富裕国家联盟为何应资助他国脱碳》
Correspondence（读者来信）
US disruptions to science could transform global research landscape
《美国科学动荡或重塑全球科研格局》
Global cooperation is crucial for DeepSeek and broader AI research
《全球合作对深度求索及AI研究至关重要》
AI demands a different approach to education
《AI需要教育方式的革新》
Japan needs a fresh approach to innovation
《日本需创新新思路》
Work（职场与工具）
How researchers can work fairly with Indigenous and local knowledge
《研究者如何公平对待原住民与地方知识》
How I connect Colombia’s remote communities to safer water
《我如何为哥伦比亚偏远社区提供安全用水》
Research（研究论文）
News & Views（新闻与观点）
Fish gills and human ears share the same genetic blueprint
《鱼鳃与人类耳朵共享相同遗传蓝图》
Ancient peat reveals that sea level surged rapidly twice at the end of the last ice age
《古代泥炭揭示末次冰期末海平面两次急速上升》
Putting the brakes on mitochondrial fusion to prevent escape of mitochondrial DNA
《抑制线粒体融合以阻止线粒体DNA泄漏》
Errors in the Huntington’s disease gene accumulate slowly and then all at once
《亨廷顿病基因突变缓慢累积后突然爆发》
美国纽约塔里敦再生元遗传学中心，等。
摘要：亨廷顿氏病是一种神经退行性疾病，源于HTT基因序列的突变，其中胞嘧啶、腺嘌呤和鸟嘌呤（CAG）的三个核苷酸重复到异常长度。HTT编码亨廷顿蛋白，亨廷顿蛋白在大脑中含量丰富，但功能尚不清楚。尽管自发现以来已经进行了三十年的研究，但将HTT突变与亨廷顿氏病联系起来的机制尚不清楚。Handsaker等人在《细胞》杂志上发表文章，表明只有在HTT中CAG重复扩增数十年后，才会出现神经元毒性，这可能提供了一个广阔的治疗窗口。易生信-临床基因组学数据分析实战，5月开课。
An experiment in mass education using satellite TV
《卫星电视普及教育的实验》
Key process in sex-cell formation can finally be studied in vitro
《性细胞形成关键过程终可在体外研究》
Reviews（综述）
Long-term studies provide unique insights into evolution
《长时间线研究为进化提供独特见解》
Articles（研究论文）
Disorder-assisted real–momentum topological photonic crystal
《无序辅助的实动量拓扑光子晶体》
Optimizing generative AI by backpropagating language model feedback
《通过语言模型反馈反向传播优化生成式AI》
A mixed-precision memristor and SRAM compute-in-memory AI processor
《混合精度忆阻器与SRAM存算一体AI处理器》
A generative model for inorganic materials design
《无机材料设计的生成模型》
Homogeneous ZnSeTeS quantum dots for efficient and stable pure-blue LEDs
《均质ZnSeTeS量子点实现高效稳定纯蓝光LED》
Large recoverable elastic energy in chiral metamaterials via twist buckling
《手性超材料通过扭结实现大弹性储能》
Fingerprinting the recovery of Antarctic ozone
《南极臭氧恢复的“指纹”鉴定》
Global sea-level rise in the early Holocene revealed from North Sea peats
《北海泥炭揭示全新世早期全球海平面上升》
High temporal variability not trend dominates Mediterranean precipitation
《地中海降水以高时间变率为主，而非长期趋势》
Increasing hourly heavy rainfall in Austria reflected in flood changes
《奥地利小时强降水增加引发洪水变化》
Children’s arithmetic skills do not transfer between applied and academic mathematics
《儿童算术能力无法在应用与学术数学间迁移》
Repurposing of a gill gene regulatory program for outer-ear evolution
《鳃基因调控程序被重新用于外耳进化》
Genome duplication in a long-term multicellularity evolution experiment
《长期多细胞进化实验中的基因组复制》
Complete human recombination maps
《完整人类重组图谱》
A comprehensive spatio-cellular map of the human hypothalamus
《人类下丘脑时空细胞综合图谱》
An opponent striatal circuit for distributional reinforcement learning
《分布强化学习的纹状体拮抗回路》
CARD domains mediate anti-phage defence in bacterial gasdermin systems
《CARD结构域介导细菌Gasdermin系统的抗噬菌体防御》
Precise modelling of mitochondrial diseases using optimized mitoBEs
《优化线粒体碱基编辑器精准模拟线粒体疾病》
IL-27 elicits a cytotoxic CD8+ T cell program to enforce tumour control
《IL-27激活CD8+ T细胞毒性程序增强肿瘤控制》
Human-correlated genetic models identify precision therapy for liver cancer
《人类关联基因模型发现肝癌精准疗法》
Intrinsic electrical activity drives small-cell lung cancer progression
《内在电活动驱动小细胞肺癌进展》
Dual regulation of mitochondrial fusion by Parkin–PINK1 and OMA1
《Parkin-PINK1与OMA1对线粒体融合的双重调控》
Reconstitution of SPO11-dependent double-strand break formation
《SPO11依赖性双链断裂形成的体外重建》
SPO11 dimers are sufficient to catalyse DNA double-strand breaks in vitro
《SPO11二聚体足以在体外催化DNA双链断裂》
In vitro reconstitution of meiotic DNA double-strand-break formation
《减数分裂DNA双链断裂形成的体外重建》
Structure and mechanism of vitamin-K-dependent γ-glutamyl carboxylase
《维生素K依赖性γ-谷氨酰羧化酶的结构与机制》
Molecular basis of vitamin-K-driven γ-carboxylation at the membrane interface
《膜界面维生素K驱动γ-羧化的分子基础》
Corrections（更正）
Author Correction: The genetic origin of the Indo-Europeans
《作者更正：印欧语系人群的基因起源》
Author Correction: HIV-1 Env trimers asymmetrically engage CD4 receptors in membranes
《作者更正：HIV-1 Env三聚体非对称结合膜CD4受体》
Author Correction: The Ronne Ice Shelf survived the last interglacial
《作者更正：龙尼冰架挺过上一次间冰期》
Author Correction: A comprehensive spatio-cellular map of the human hypothalamus
《作者更正：人类下丘脑时空细胞综合图谱》
Author Correction: Neutralizing GDF-15 can overcome anti-PD-1 and anti-PD-L1 resistance in solid tumours
《作者更正：中和GDF-15可克服实体瘤抗PD-1/PD-L1耐药性》
Author Correction: CTLA4 blockade abrogates KEAP1/STK11-related resistance to PD-(L)1 inhibitors
《作者更正：CTLA4阻断消除KEAP1/STK11介导的PD-(L)1抑制剂耐药性》
Volume 639 Issue 8056, 27 March 2025
https://www.nature.com/nature/volumes/639/issues/8056
Editorial（社论）
What CERN does next matters for science and for international cooperation
《CERN下一步行动关乎科学与国际合作》
Track gender ratios in research to keep countries, institutions and publishers accountable
《追踪研究性别比例以问责国家、机构与出版商》
World View（全球视野）
Climate change will send home insurance spiralling. Here’s how to control costs
《气候变化推高房屋保险—控制成本之道》
Empower families to lead the design of their ageing loved ones’ health care
《赋能家庭主导老龄亲属的医疗设计》
Research Highlights（研究亮点）
Drugs that target ‘zombie’ cells soothe an aching back
《靶向“僵尸细胞”药物缓解背痛》
Food-industry waste finds a second life as bioplastic
《食品工业废料“重生”为生物塑料》
Ship-pollution cuts have an electrifying effect: less lightning at sea
《船舶污染减少降低海上闪电频率》
Iguanas reached Fiji by floating 8,000 kilometres across the sea
《鬣蜥漂流8000公里抵达斐济》
News in Focus（焦点新闻）
Light pollution threatens fleet of world-class telescopes in Atacama Desert
《光污染威胁阿塔卡马沙漠顶级望远镜群》
NIH has cut one mRNA-vaccine grant. Will more follow?
《NIH削减一项mRNA疫苗资助—更多将跟进？》
Measles is surging in the US: how bad could it get?
《美国麻疹激增：可能有多严重？》
Catchy, clear, concise: three-part phrases boost research paper citations
《朗朗上口、简洁清晰：三词短语提升论文引用量》
Man survives with titanium heart for 100 days — a world first
《钛合金心脏存活100天—全球首例》
Is dark energy getting weaker? Fresh data bolster shock finding
《暗能量在减弱？新数据支持惊人发现》
Immune cells ‘bandage’ wounds with bacteria-trapping goo
《免疫细胞用“黏液绷带”捕获细菌 修复伤口》
Features（专题）
AI is transforming peer review — and many scientists are worried
《AI正在改变同行评审—科学家担忧加剧》
Fasting for weight loss is all the rage: what are the health benefits?
《禁食减肥风靡一时：健康益处何在？》
Books & Arts（书评与艺术）
The expanding Universe — do ongoing tensions leave room for new physics?
《膨胀的宇宙—持续争议是否为新物理学留出空间？》
Opinion（观点）
Comment（评论）
Glaciers are not just blocks of ice — plans to save them mustn’t overlook their hidden life
《冰川不仅是冰块—保护计划不可忽视其隐秘生命》
Microbes can capture carbon and degrade plastic — why aren’t we using them more?
《微生物可固碳降解塑料—为何未被充分利用？》
Correspondence（读者来信）
How to get more women into mining
《如何让更多女性进入采矿业》
Give grants to female scientists in war zones
《资助战区女科学家》
Lesotho matters
《莱索托的重要性》
Lessons from Portugal on effects of cutting research funding
《葡萄牙削减科研资助的教训》
Work（职场与工具）
Shaking up earthquake safety in Nepal with a folk song
《用民歌撼动尼泊尔的地震安全》
RNA function follows form – why is it so hard to predict?
《RNA功能遵循结构—为何难以预测？》
Reviving the biodiversity around an ancient palace
《复兴古宫周围的生物多样性》
Research（研究论文）
News & Views（新闻与观点）
Evolutionary flexibility to gain or lose tooth complexity sparks fish diversification
《牙齿复杂度演化的灵活性驱动鱼类多样化》
A lighthouse galaxy shines unexpectedly through the fog of the cosmic dawn
《“灯塔星系”意外穿透宇宙黎明迷雾》
Protein waste turned into antibiotics as a defence strategy of human cells
《人类细胞将蛋白废料转化为抗生素的防御策略》
Nursing-home residents’ skin is a source of transmitted harmful and drug-resistant microbes
《养老院居民皮肤是耐药有害微生物的传播源》
Why is my cello howling?
《大提琴为何“嚎叫”？》
Fossilized dinosaur cells that defied the ravages of time — 20 years since a key discovery
《挑战时间侵蚀的恐龙细胞化石—关键发现20周年》
Perspective（观点研究）
The other climate crisis
《另一场气候危机》
Multimodal generative AI for medical image interpretation
《多模态生成式AI助力医学影像解读》
Articles（研究论文）
Witnessing the onset of reionization through Lyman-α emission at redshift 13
《通过红移13的莱曼-α辐射见证再电离的起始》
Vertical structure of an exoplanet’s atmospheric jet stream
《系外行星大气急流的垂直结构》
Electroluminescence and energy transfer mediated by hyperbolic polaritons
《双曲极化激元介导的电致发光与能量转移》
Hyperbolic phonon-polariton electroluminescence in 2D heterostructures
《二维异质结构中的双曲声子极化激元电致发光》
Down-converted photon pairs in a high-Q silicon nitride microresonator
《高Q氮化硅微腔中的下转换光子对》
An ultra-broadband photonic-chip-based parametric amplifier
《超宽带光子芯片参量放大器》
Adaptive locomotion of active solids
《活性固体的自适应运动》
Record sea surface temperature jump in 2023–2024 unlikely but not unexpected
《2023–2024年海表温度跃升虽罕见但非意外》
Sliding and healing of frictional interfaces that appear stationary
《静摩擦界面的滑动与自愈》
Vulnerability of amphibians to global warming
《全球变暖下两栖动物的脆弱性》
Evolutionary lability of a key innovation spurs rapid diversification
《关键创新的演化可塑性驱动快速多样化》
Genomics yields biological and phenotypic insights into bipolar disorder
《基因组学揭示双相情感障碍的生物学与表型机制》
挪威奥斯陆大学医院 心理健康和成瘾科，精神病学中心，等
摘要：双相情感障碍是全球疾病负担的主要因素。尽管遗传率很高（60-80%），但大多数潜在的遗传决定因素仍然未知。我们分析了来自欧洲、东亚、非裔美国人和拉丁裔祖先的参与者的数据（n=158,036例双相情感障碍患者，280万对照组），结合临床、社区和自我报告的样本。我们在多血统荟萃分析中确定了298个全基因组显著位点，比之前的发现增加了四倍，并在东亚队列中确定了一种血统特异性关联。整合精细定位和其他变异到基因定位方法的结果，确定了双相情感障碍病因中的36个可信基因。通过精细定位优先的基因，在双相情感障碍病例中富集了极罕见的有害错义和蛋白质截断变异，突出了常见和罕见变异信号的趋同。我们报告了双相情感障碍的遗传结构差异，这取决于患者确定的来源和双相情感疾病亚型（I型或II型）。一些分析表明，双相情感障碍的病理生理学中涉及特定的细胞类型，包括GABA能中间神经元和中棘神经元。这些分析共同为双相情感障碍的遗传结构和生物学基础提供了额外的见解。易生信-临床基因组学数据分析实战，5月开课。
Measuring racial educational disparities over time amongst top achievers
《顶尖学生种族教育差距的长期测量》
Glycocalyx dysregulation impairs blood–brain barrier in ageing and disease
《糖萼失调损害衰老与疾病中的血脑屏障》
Left–right-alternating theta sweeps in entorhinal–hippocampal maps of space
《内嗅-海马空间图谱中的左右交替θ波》
A crucial role for the cortical amygdala in shaping social encounters
《皮层杏仁核在社交行为中的关键作用》
Clonal Candida auris and ESKAPE pathogens on the skin of residents of nursing homes
《养老院居民皮肤上的克隆耳念珠菌与ESKAPE病原体》
Differential protection against SARS-CoV-2 reinfection pre- and post-Omicron
《Omicron前后对SARS-CoV-2再感染的差异保护》
Cell-autonomous innate immunity by proteasome-derived defence peptides
《蛋白酶体来源防御肽的细胞自主先天免疫》
RNA neoantigen vaccines prime long-lived CD8+ T cells in pancreatic cancer
《RNA新抗原疫苗激活胰腺癌长期CD8+ T细胞》
Clonal driver neoantigen loss under EGFR TKI and immune selection pressures
《EGFR-TKI与免疫选择压力下克隆驱动新抗原的丢失》
GABAergic neuron-to-glioma synapses in diffuse midline gliomas
《弥漫中线胶质瘤中的GABA能神经元-肿瘤突触》
Plasmodium blood stage development requires the chromatin remodeller Snf2L
《疟原虫血液期发育依赖染色质重塑因子Snf2L》
A metagenomic ‘dark matter’ enzyme catalyses oxidative cellulose conversion
《宏基因组“暗物质”酶催化纤维素氧化转化》
巴西能源与材料研究中心，巴西生物可再生能源国家实验室，等
长期甘蔗渣覆盖土壤的宏基因组
晶体结构、铜性能和催化要求
易生信-宏基因组课程开课时间：2025-05-09
易生信-临床基因组学数据分析实战，2025-05-16
Mechanism for local attenuation of DNA replication at double-strand breaks
《DNA双链断裂处局部复制抑制的机制》
Structure and mechanism of the Zorya anti-phage defence system
《Zorya抗噬菌体防御系统的结构与机制》
高颜值免费 SCI 在线绘图(点击图片直达)
最全植物基因组数据库IMP (点击图片直达)
往期精品(点击图片直达文字对应教程)
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
扫一扫
被折叠的 条评论
为什么被折叠?
到【灌水乐园】发言
