ADNI-Study-Data

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已于 2022-04-21 21:16:10 修改

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分类专栏： AD识别文章标签：健康医疗

于 2022-04-09 21:03:11 首次发布

本文链接：https://blog.csdn.net/qq_31537885/article/details/123800102

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梳理ADNI文档资料：表格数据 tabular data + 文档及压缩文件

Study Info: Data & Databases

Key ADNI tables merged into one table

aka ADNIMERGE.csv ☆☆☆☆☆

患者基本信息

RID (Participant roster ID) ex. 2、PTID (Original study protocol) ex. 011_S_0002、VISCODE (Visit code) ex. bl、SITE ex. 11、COLPROT (Study protocol of data collection) ex. ADNI1、ORIGPROT (Original study protocol) ex. ADNI1、EXAMDATE (Date) ex. 9/8/2005、DX (Diagnosis) ex. CN
AGE 54.4-91.4、PTGENDER (Sex) Female \ male、PTEDUCAT (Education) 4-20、PTETHCAT (Ethnicity) 、PTRACCAT (Race)、PTMARRY (Marital)

生物标记物量化值

ABETA (CSF ABETA)、 APOE4 (0, 1, 2)、FDG (Average FDG-PET of angular, temporal, and posterior cingulate)、PIB (Average PIB SUVR of frontal cortex, anterior cingulate, precuneus cortex, and parietal cortex)、 AV45 (Reference region - florbetapir mean of whole cerebellum. Regions defined by Freesurfer; see Jagust lab PDF on LONI for details)、TAU (CSF TAU)、PTAU (CSF PTAU)

认知评估

CDRSB (Clinical dementia rating sum of boxes)、MMSE (Mini-mental state evaluation)、FAQ (Functional Activities Questionnaire)、MOCA (Montreal cognitive assessment)、LDELTOTAL (Logical Memory - Delayed Recall)、DIGITSCOR (Digit Symbol Substitution)
ADAS11、ADAS13、ADASQ4 (ADAS Delayed Word Recall)
mPACCdigit (ADNI modified Preclinical Alzheimer's Cognitive Composite (PACC) with Digit Symbol Substitution)、mPACCtrailsB (ADNI modified Preclinical Alzheimer's Cognitive Composite (PACC) with Trails B)、TRABSCOR (Trails B)
RAVLT (forgetting)、RAVLT_immediate (sum of 5 trials)、RAVLT_learning (RAVLT Learning (trial 5 - trial 1))、RAVLT_forgetting (RAVLT Forgetting (trial 5 - delayed))、RAVLT_perc_forgetting (RAVLT Percent Forgetting)
EcogPtMem、EcogPtLang、EcogPtVisspat、EcogPtPlan、EcogPtOrgan、EcogPtDivatt、EcogPtTotal、EcogSPMem、EcogSPLang、EcogSPVisspat、EcogSPPlan、EcogSPOrgan、EcogSPDivatt、EcogSPTotal

解剖结构量化值

IMAGEUID、Ventricles 心室、Hippocampus 海马体、WholeBrain 、Entorhinal 嗅内区、 Fusiform 梭状回、 MidTemp 颞中回 、 ICV → 可以和 PET数据的定量数据 一起分析，对结构向数据和功能向数据的结合使用可以有效降低自然衰老带来的个体间差异

Other

FSVERSION (FreeSurfer Software Version)、FLDSTRENG (MRI Field Strength)、Month (Months since baseline)、M (Months since baseline)

And 上述各信息的bl值

Key ADNI tables merged into one table - Dictionary

aka ADNIMERGE_DICT.csv

Data Dictionary [ADNI1,GO,2,3]

aka DATADIC.csv 为 ADNIMERGE_DICT.csv 条目解释进行补充

Merged ADNI 1/GO/2 Methods (PDF)

aka ADNIMERGE_Methods_21030429.pdf

ALL Diagnosis

Diagnosis and Symptoms Checklist [ADNI1,GO,2]

Total 4884 items：ADNI1 (4201 items) + ADNIGO (683 items)

header

Phase ID RID SITEID VISCODE VISCODE2 USERDATE USERDATE2 EXAMDATE AXNAUSEA AXVOMIT AXDIARRH AXCONSTP AXABDOMN AXSWEATN AXDIZZY AXENERGY AXDROWSY AXVISION AXHDACHE AXDRYMTH AXBREATH AXCOUGH AXPALPIT AXCHEST AXURNDIS AXURNFRQ AXANKLE AXMUSCLE AXRASH AXINSOMN AXDPMOOD AXCRYING AXELMOOD AXWANDER AXFALL AXOTHER AXSPECIF update_stamp

Diagnostic Summary - Baseline Changes [ADNI1,GO,2,3]

Total 12161 items：ADNI1 (3871 items) + ADNI2 (5666 items) + ADNI3 (2149 items) + ADNIGO (475 items)

header

Phase ID RID SITEID VISCODE VISCODE2 USERDATE USERDATE2 EXAMDATE BCPREDX BCADAS BCMMSE BCMMSREC BCNMMMS BCNEUPSY BCNONMEM BCFAQ BCCDR BCDEPRES BCSTROKE BCDELIR BCEXTCIR BCEXTSP BCCORADL BCCORCOG BCSUMM update_stamp

Diagnostic Summary [ADNI1,GO,2,3]

Total 12156 items：ADNI1 (3868 items) + ADNI2 (5671 items) + ADNI3 (2142 items) + ADNIGO (475 items)

header

Phase ID RID SITEID VISCODE VISCODE2 USERDATE USERDATE2 EXAMDATE DXCHANGE DXCURREN DXCONV DXCONTYP DXREV DXNORM DXNODEP DXMCI DXMDES DXMPTR1 DXMPTR2 DXMPTR3 DXMPTR4 DXMPTR5 DXMPTR6 DXMDUE DXMOTHET DXMOTHSP DXDSEV DXDDUE DXAD DXADES DXAPP DXAPROB DXAMETASP DXAOTHRSP DXAPOSS DXAATYSP DXAMETSP DXAOTHSP DXPARK DXPARKSP DXPDES DXPCOG DXPATYP DXPOTHSP DXDEP DXDEPSP DXOTHDEM DXODES DXOOTHSP DXCONFID DIAGNOSIS update_stamp

summary

	ADNI1	ADNIGO	ADNI2	ADNI3	Total
D1	4201	683	/	/	4884
D2	3871	475	5666	2149	12161
D3	3868	475	5671	2142	12156
D1: Diagnosis and Symptoms Checklist [ADNI1,GO,2]
D2: Diagnostic Summary - Baseline Changes [ADNI1,GO,2,3]
D3: Diagnostic Summary [ADNI1,GO,2,3]

ALL PET Image Acquisition

FDG PET Scan Information [ADNI1]

1957 items = bl (431) + m06 (402) + m12 (376) + m18 (173) + m24 (330) + m36 (224) + m48 (21)

ID RID SITEID VISCODE USERDATE USERDATE2 RECNO PMCONDCT PMREASON PMOTHSPE PMCONSENT PMTYPE EXAMDATE PMSCANNER PMGEMODEL PMSIEMENS PMSIEMODEL PMPHILLIPS PMPHMODEL PMQCTIME PMBLTIME PMBLGLUC PMFDGTIME PMFDGDOS PMFDGVOL PMINJTIME PMGLUCOM PMSCTIME PMSCANCOM PMVARIAT PMVARSP PMPROTID PMFRAME PMDEVIAT PMMOTION PMMOTSP PMMALFUN PMMALSP PMOTHER PMOTHSP PMRECON PMSUBSET PMSUBSPE PMITERAT PMITERSPE PMRAMLA PMFILTER PMMODEON PMSMOOTH PMDECAY PMSCATTR PMATTEN PMWITHDRAW PMWITHTIME PMCOUNT PMCOUNTIME PMBG1TIME PMBG1VOL PMBG1DUR PMBG1COUNT PMP1DTIME PMP1CTIME PMP1BGL PMP1VOL PMP1DUR PMP1COUNT PMP2DTIME PMP2CTIME PMP2BGL PMP2VOL PMP2DUR PMP2COUNT PMP3DTIME PMP3CTIME PMP3BGL PMP3VOL PMP3DUR PMP3COUNT PMP4DTIME PMP4CTIME PMP4BGL PMP4VOL PMP4DUR PMP4COUNT PMP5DTIME PMP5CTIME PMP5BGL PMP5VOL PMP5DUR PMP5COUNT PMBG2CTIME PMBG2VOL PMBG2DUR PMBG2COUNT PMPIPVOL PMPIPVOLSP PMCTIME PMCTIMESP PMPHACT PMPHVOL PMPHCOUNT PMALIQVOL PMALIQACT PMBLOOD PMBLOOD2 PMTRNSFR PMTRNDATE PMTRNCOM PMARCHIVE PMARCMED PMARCCOM PMLPDONE PMLPINTER update_stamp

FDG PET Scan Information [ADNIGO,2]

3376 items = bl (131) + m36 (9) + m48 (146) + m60 (56) + v03 (792) + v06 (380) + v11 (337) + v21 (819) + v31 (214) + v41(456) + v51 (36)

3376 items = ADNI2 (3034) + ADNIGO (342)

Phase ID RID SITEID VISCODE VISCODE2 USERDATE USERDATE2 RECNO PMCONDCT PMREASON PMOTHSPE RADTRACER EXAMDATE PMSCANNER PMGEMODEL PMSIEMENS PMSIEMODEL PMPHILLIPS PMPHMODEL PMQCTIME PMBLTIME PMBLGLUC PMFDGTIME PMFDGDOS PMFDGVOL PMINJTIME PMGLUCOM PMSCTIME PMSCANCOM PMVARIAT PMVARSP PMPROTID PMFRAME PMDEVIAT PMMOTION PMMOTSP PMMALFUN PMMALSP PMOTHER PMOTHSP PMRECON PMSUBSET PMSUBSPE PMITERAT PMITERSPE PMRAMLA PMSHARP PMFILTER PMMODEON PMSMOOTH PMATTEN PMTRNSFR PMTRNDATE PMTRNCOM PMARCHIVE PMARCMED PMARCCOM PMLPDONE PMLPINTER update_stamp

FDG PET Scan Information [ADNI3]

VISCODE : 539 items = bl (291) + init (248)
VISCODE2 : 539 items = bl (290+1) + m48 (27) + m60 (50) + m72 (98) + m84 (23) + m96 (5) + m120 (6) + m132 (27) + m144 (10) + m156 (2)

Phase ID RID SITEID VISCODE VISCODE2 USERDATE USERDATE2 DONE NDREASON NDSPECIFY RADTRACER SCANDATE QCTIME PMBLTIME PMBLGLUC ASSAYTIME FDGDOS INJTIME PMGLUCOM SCANTIME SCANDIFF VARIAT VARIATSPEC PROTID MOTION OTHERVAR RECON SHARP ARCHIVE LONI TRANDATE update_stamp

Summary

PET Metadata Listing [ADNI1,GO,2]

PET Scanner Smoothing Table

PET Image Analysis

BAI - PET NMRC FDG Summaries Dictionary [ADNI1,GO,2,3]

HCI：Hypometabolic Convergence Index 代谢下降指数

BAI - PET NMRC FDG Summaries [ADNI1,GO,2,3]

3648 items = bl (1471) + m06 (368) + m12 (339) + m18 (154) + m24 (660) + m36 (190) + m48 (127) + m60 (110) + m72 (125) + m84 (67) + m96 (14)

BAI - PET NMRC FDG Summaries Methods (PDF)

NYU FDG-PET Hippocampus (pons normalized) Dictionary [ADNI1]

NYU FDG-PET Hippocampus (pons normalized) [ADNI1]

612 items

NYU FDG-PET Hippocampus (pons normalized) Methods (PDF)

Hippocampal Glucose Metabolism Sampling, the NYU HIPMASK
NYU HIPMASK海马葡萄糖代谢采样

UC Berkeley - FDG Analysis Dictionary [ADNI1,GO,2]

UC Berkeley - FDG Analysis [ADNI1,GO,2,3]

VISCODE2：18170 items = bl (7280 + 5) + m06 (1840) + m12 (1695) + m18 (770) + m24 (3300) + m36 (950) + m48 (635) + m60 (550) + m72 (625) + m84 (335) + m96（70）→ 18170/5 = 3634

UC Berkeley - FDG Methods (PDF)

UU - PET AD Subjects Cerebral Metabolic Pattern of Glucose Uptake Consistent with Frontotemporal Dementia in Baseline FDG-PET (PDF)

PET Image Quality

FDG PET QC [ADNI3]

VISCODE : 346 items = bl (207) + init (139)
VISCODE2 : 346 items = bl (206+1) + m48 (5) + m60 (31) + m72 (59) + m84 (16) + m96 (3) + m120 (7) + m132 (13) + m144 (4) + m156 (1)

Phase ID RID SITEID VISCODE VISCODE2 USERDATE USERDATE2 SCANDATE LONIUPDT LONIUID REVDT ALLFRAME UNUSABL UNRSN UNRSNSPEC SCANQLTY REPROCREQ PROCERR PROCERRSPEC RESCANREQ update_stamp

初步分析
时间顺序（早-晚）：SCANDATE（ex.1/26/2017） — LONIUPDT (ex. 3/21/2017) — REVDT (ex. 3/21/2017) — USERDATE = USERDATE2 (ex. 3/24/2017)

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