157606-25-2、Cecropin A (1-7)-Melittin A (2-9)，蜂毒素A（2-9）

Cecropin A (1-7)-Melittin A (2-9) amide, also referred to as CAMEL0, is a synthetic hybrid peptide that is composed of portions of the naturally occurring antibiotic peptide cecropin A and melittin. CAMEL0 shows a better antimicrobial activity than the native molecules, but lacks the hemolytic properties of melittin. Studies revealed that the range of its antimicrobial activity is not only restricted to aerobic microorganisms but also included several gram-negative and gram-positive anaerobic microorganisms. Through its ascertained broad spectrum of antibiotic activity, this hybrid peptide may also represent an effective substitute for ciprofloxacin in the treatment of anthrax infections.

抗菌肽和蜂毒素都具有抗菌效果。抗菌肽A与蜂毒素A组成而成的杂合肽，具有很强的抑菌活性。抗菌肽中一般含有比较多的碱性氨基酸，因此亲水性是比较强的，这部分是抗菌肽的生物活性片段；而蜂毒素独特的疏水性以及抗菌活性，可以让多肽进入细菌质膜中，两种片段结合，能够起到消灭细菌的效果，Cecropin A (1-7)-Melittin A (2-9) amide就是这样一条具有灭菌效果的杂合肽，由15个氨基酸组合而成

编号: 119043
中文名称: Cecropin A (1-7)-Melittin A (2-9)，蜂毒素A（2-9
英文名: Cecropin A (1-7)-Melittin A (2-9)
英文同义词: Cecropin A (1-8)-Melittin A (3-9) amide, Cecropin A-melittin hybrid peptide [CA(1-7)M(2-9)NH2], CAMEL0, CM15
CAS号: 157606-25-2
单字母: H2N-KWKLFKKIGAVLKVL-NH2
三字母: H2N-Lys-Trp-Lys-Leu-Phe-Lys-Lys-Ile-Gly-Ala-Val-Leu-Lys-Val-Leu-NH2
氨基酸个数: 15
分子式: C89H152N22O15
平均分子量: 1770.3
精确分子量: 1769.18
等电点(PI): -
pH=7.0时的净电荷数: 5.97
平均亲水性: -0.11428571428571
疏水性值: 0.54
来源: 人工化学合成，仅限科学研究使用，不得用于人体。
盐体系: 可选TFA、HAc、HCl或其它
储存条件: 负80℃至负20℃
标签: 抗菌肽(Antimicrobial Peptides)