dna编码库_药明康德推出DNA编码化合物库服务包DELight，加速早期新药发现进程...

▎药明康德/报道

药明康德推出DNA编码化合物库服务包DELight，加速早期新药发现进程 药明康德今日宣布推出DNA编码化合物库服务包DELight，通过领先的DNA编码化合物库技术(DNA Encoded-Library，简称DEL)为全球客户提供更具性价比、更高效的苗头化合物筛选服务，从而加速新药发现进程，推动新药、好药早日上市，造福全球病患。 DELight服务包是药明康德DEL平台推出的一款自助式服务产品。通过DELight服务包，用户可获得一个内含80多亿个DNA编码小分子化合物的DEL试剂盒，并可根据使用手册自助完成靶点亲和筛选实验，再将实验结果返还给药明康德。药明康德完成后续的聚合酶链式反应(PCR扩增)、定量聚合酶链反应(qPCR定量)、纯化以及测序等实验和分析后，会向用户反馈一份总结性报告(不包含小分子化合物结构及DNA序列信息)，用户可根据报告结果决定是否开展后续研究。 相比于传统的服务模式，DELight的操作简便高效，成本显著降低，整个过程中用户也无需透露任何靶点信息，信息传输安全可靠，能帮助客户快速进行苗头化合物筛选，大幅缩短了早期新药发现的时间。 “DELight的推出能进一步提升DNA编码化合物技术在新药研发领域的应用和发展，为客户更快完成早期药物发现提供了有力的技术支持。”药明康德DEL团队负责人彭宣嘉博士表示：“DELight通过高性价比的服务，将有助于降低新药研发的门槛，使广大创新、创业者都能够受益于更前沿高效的新药研发技术，从而加速新药研发进程，造福病患。” 目前，药明康德DEL平台已拥有900亿个DNA编码小分子化合物，其中大多数母核化合物是由药明康德DEL团队根据结构热度和成药性进行自主设计和定制合成，具有新颖独特的化学空间和结构性质，可以帮助客户实现更精准的小分子化合物筛选服务。该平台已成功为客户筛选了多个不同种类的蛋白，并找到了多个纳摩尔级别的苗头化合物，有效提升了新药研发的效率。   关于药明康德 药明康德(股票代码：603259.SH/2359.HK)为全球生物医药行业提供全方位、一体化的新药研发和生产服务。通过赋能全球制药、生物科技和医疗器械公司，药明康德致力于推动新药研发进程，为患者带来突破性的诊疗方案。本着以研究为首任，以客户为中心的宗旨，药明康德通过高性价比和高效的研发服务，助力客户提升研发效率，服务范围涵盖化学药研发和生产、细胞及基因疗法研发生产、医疗器械测试等领域。目前，药明康德的赋能平台正承载着来自全球30多个国家的3600多家合作伙伴的研发创新项目，致力于将更多新药、好药带给全球病患，早日实现“让天下没有难做的药，难治的病”的梦想。更多信息，请访问公司网站：www.wuxiapptec.com 关于药明康德DNA编码化合物库平台服务 药明康德DNA编码化合物库平台服务于生命科学行业，利用亲和筛选性筛选方法从百亿级DNA编码小分子化合物库中挑选出具有成药潜力的靶标化合物，致力于为全球合作伙伴提供DEL筛选技术涉及的从建库到筛选，高效、灵活、高质量的一站式创新药研发解决方案。其业务主要遍布于中国，欧洲及北美国家，客户从生物技术公司到大型制药公司。 

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WuXi AppTec Launches DNA Encoded Library (DEL) Service Package “DELight” to Expedite Early Drug Discovery

WuXi AppTec today announced its launch of DELight, a novel DNA Encoded Library (DEL) service package, providing cost-effective and efficient hit finding services to expedite early drug discovery and bring new medicines to patients faster. DELight is WuXi DEL’s self-serve product that gives researchers direct access to a collection of more than eight billion compounds. Through the DELight service package, WuXi will provide a DNA Encoded Library kit and a user manual/protocols document to the research organization. Upon receipt of the kit, the researcher will perform affinity selection according to the protocol and return the sample to WuXi. WuXi then completes analysis such as PCR amplification, qPCR determination, purification and NGS (Next Generation Sequencing). A summary report (excluding structural and DNA sequence information) will be provided back to the researcher, who will make informed decision on follow up actions based on the selection results. Compared to traditional DEL services, DELight is a more convenient, efficient and economical service package, allowing researchers to perform their own affinity selection with minimum assay development and without disclosing target information. “The launch of DELight can further enhance the application and development of DEL technology in the new drug discovery industry and provide strong technical support for customers to accelerate early drug discovery,” said Xuanjia Peng, head of the WuXi DEL team. “DELight offers innovators and entrepreneurs an affordable and instant access to advanced DEL technology that can improve the productivity of new drug discovery and bring new medicines to patients faster.” The WuXi DEL platform now features 90 billion unique molecules covering major medicinal-chemically preferred cores, most of which are self-designed and custom-synthesized, making these libraries structurally diverse and chemically exclusive. Through evolutionary screening, the unique drug-like libraries expand the accessible number of drug candidates, leading to better and faster development of new medicines. So far, various targets from different classes have been screened and multiple nanomolar hits have been identified.  About WuXi AppTec WuXi AppTec provides a broad portfolio of R&D and manufacturing services that enable companies in the pharmaceutical, biotech and medical device industries worldwide to advance discoveries and deliver groundbreaking treatments to patients. As an innovation-driven and customer-focused company, WuXi AppTec helps our partners improve the productivity of advancing healthcare products through cost-effective and efficient solutions. With industry-leading capabilities such as R&D and manufacturing for small molecule drugs, cell and gene therapies, and testing for medical devices, WuXi AppTec’s open-access platform is enabling more than 3,600 collaborators from over 30 countries to improve the health of those in need – and to fulfill our dream that "every drug can be made and every disease can be treated." Please visit: http://www.wuxiapptec.com About WuXi DNA-Encode Library (DEL) Technology Service WuXi DEL Technology Service provides customers with a cutting-edge hit identification and optimization platform using an affinity-based selection method against DNA-Encoded small molecule libraries. With operations in China, Europe and North America, clients range from small biotechnology companies to large pharmaceutical companies.