css-palm,[转载]【转】蛋白质翻译后修饰棕榈酰化位点预测工具 —— CS

As a special class of post-translational modifications (PTMs),

numerous proteins could be covalently modified by a variety of

lipids, including myristate (C14), palmitate (C16), farnesyl (C15),

geranylgeranyl (C20) and glycosylphosphatidylinositol (GPI), etc

(Casey, 1995 ; Nadolski and Linder, 2007 ; Resh, 2006 ). Although

most of lipid modifications are irreversible, protein

S-palmitoylation , also called as thioacylation or S-acylation,

could reversibly attach 16-carbon saturated fatty acids to specific

cysteine residues in protein substrates through thioester linkages

(Bijlmakers and Marsh, 2003 ; Dietrich and Ungermann, 2004 ;

el-Husseini Ael and Bredt, 2002 ; Greaves and Chamberlain, 2007 ;

Linder and Deschenes, 2007 ; Nadolski and Linder, 2007 ; Resh, 2006

; Resh, 2006 ; Roth, et al., 2006 ; Smotrys and Linder, 2004 ; Wan,

et al.,