Epifactors:表观因子数据库

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对于DNA甲基化，组蛋白修饰，染色质重塑等表观遗传标记分子的研究迅猛发展，在相关领域已经积累了大量的认知。通过对研究表明的参与这些表观遗传机制的蛋白对应的基因，功能进行整理和归纳，构建了Epifactors数据库，网址如下

http://epifactors.autosome.ru/

为了提供更加全面和丰富的认知，在传统的直接参与表观遗传的蛋白的基础上，定义了表观因子这个概念，将直接参与表观遗传的核心蛋白和其周边蛋白联系起来，进一步丰富了表观遗传中相关分子的网络结构。

将以下几种蛋白定义为表观因子

1. Proteins acting as histones, histone variants or protamines;

2. Proteins performing post-translational modifications of histones or recognizing such modifications (histone modification ‘writers’, ‘erasers’ or ‘readers’);

3. Proteins changing the general structure of chromatin (performing chromatin remodeling), including Proteins that move, eject or restructure nucleosomes (ATP-dependent chromatin remodelers) and proteins that incorporate histone variants into the nucleosomes.

4. Proteins assist