Paper reading (二)：Bioinformatics advances in genomics--a review

• International Journal of Current Pharmaceutical Review and Research 
• 2016.05
• Author: Raphael John Ogbe1, Dickson O. Ochalefu2, Olumide B. Olaniru3
• bstract: Key Words: Annotation, Assembly, Biotechnology, DNA sequence, Genome analysis
  Genomics is a discipline in genetics that applies recombinant DNA technology, DNA sequencing methods and bioinformatics to sequence, assemble and analyze the function and structure of genome, the complete set of DNA within a single cell of an organism.
• Conclusion: 1.there are still challenges in applications of specific methods. 
  2.more methods should to be developed to
  tackle the problems encountered in the applications of bioinformatics
  in genomics research.
  3.an explosion of data and a rapid growth in bioinformatics
  基本上也提到了爆炸式的数据，生信领域的飞速发展，但是具体方法在组学问题上的应用还是有挑战，对于新方法的需求也很迫切。而bioinformatics方面的发展对于很多行业都很重要。bioinformatics包括genomics, transcriptomics, metabolomics,and post-genomic technologies
• Introduction: 1.data overload 导致了bioinformatics的出现，bioinformatics is at the intersection between biology and computation；the structuring of biological information to enable logical interrogation
  2.the purpose of this study is to discuss the bioinformatics advances in genomics and highlights some of the applications of bioinformatics advances to biological fields.
  3.Among the current research lines are the following:
  1). Gene prediction and modeling of splicing, related to the research on regulation of alternative splicing, and protein synthesis 
  2). Identification and characterization of genomic regions involved in Gene Regulation, related to the research on Chromatin, Gene Expression, and on the RNA-Proteins Interactions 
  3). Molecular Evolution, which includes evolution of the exonic structure of genes and the evolution of splicing.
• Structure: 1.Genomics
  2.Bioinformatics
  3.Bioinformatics contributes to advances in genomics
  Sequence analysis; phylogenetic tree; BLAST analysis; Genome sequence approaches(short-gun and high throughput sequence);  Genome analysis; Human Genome analysis; Sequence assembly; Sequence assembly approaches; Genome annotation.
  4.Other applications of bioinformatics
  Computational evolutionary biology; Genomic medicine；Understanding the genetic factors of diseases；Analysis of mutations in cancer; Analysis of gene expression；Synthetic biology and bioengineering