Defensins and LL-37 play key roles in maintaining mucosal barriers against invasive infection and initiating immune responses after infection or injury to mucosal surfaces.
Defensins在自然界中广泛存在,具有对抗多种病原体的活性。防御素具有直接的抗微生物作用,还调节先天和适应性免疫反应。
LL-37 is a C-terminal peptide proteolytically released from 18 kDa human cathelicidin protein (hCAP18). Chronic infections, inflammation, tissue injury and tissue regeneration are all linked with neoplastic growth, and involve LL-37 antibacterial and immunomodulatory functions. Such a link points to the possible involvement of LL-37 peptide in carcinogenesis. An increasing amount of evidence suggests that LL-37 can have two different and contradictory effects—promotion or inhibition of tumor growth. The mechanisms are tissue-specific, complex, and depend mostly on the ability of LL-37 to act as a ligand for different membrane receptors whose expression varies on different cancer cells. Overexpression of LL-37 was found to promote development and progression of ovarian, lung and breast cancers, and to suppress tumorigenesis in colon and gastric cancer.
LL-37是从18kDa人组织蛋白酶蛋白(hCAP18)蛋白水解释放的C末端肽。慢性感染、炎症、组织损伤和组织再生都与肿瘤生长有关,并涉及LL-37的抗菌和免疫调节功能。这种联系表明LL-37肽可能参与致癌作用。越来越多的证据表明,LL-37可以具有两种不同且相互矛盾的作用——促进或抑制肿瘤生长。机制是组织特异性的、复杂的,并且主要取决于LL-37作为不同膜受体的配体的能力,所述不同膜受体在不同癌症细胞上的表达不同。发现LL-37的过表达促进卵巢癌、肺癌和乳腺癌的发展和进展,并抑制结肠癌和癌症中的肿瘤发生。
别名:CAP-18;antibacterial peptide LL-37;Cathelicidin LL-37; LL 37; Peptide LL 37 (human gene FALL39 antibacterial)
纯度:>95% 或 >98%
单字母序列:LLGDFFRKSKEKIGKEFKRIVQRIKDFLRNLVPRTES
三字母序列:Leu-Leu-Gly-Asp-Phe-Phe-Arg-Lys-Ser-Lys-Glu-Lys-Ile-Gly-Lys-Glu-Phe-Lys-Arg-Ile-Val-Gln-Arg-Ile-Lys-Asp-Phe-Leu-Arg-Asn-Leu-Val-Pro-Arg-Thr-Glu-Ser
CAS No.: 154947-66-7
分子式:C205H340N60O53
分子量:4493.33
外观:白色粉末
氨基酸组成分析:
引用文献:
1,Human defensins and LL-37 in mucosal immunity
Mona Doss, Mitchell R White, Tesfaldet Tecle, Kevan L Hartshorn
Journal of Leukocyte Biology, Volume 87, Issue 1, Jan 2010, Pages 79–92
2,The Role of Cathelicidin LL-37 in Cancer Development
Ewelina Piktel, Katarzyna Niemirowicz, Urszula Wnorowska1, Marzena Wątek, Tomasz Wollny, Katarzyna Głuszek, Stanisław Góźdź, Ilya Levental & Robert Bucki
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