154947-66-7 | 高纯度人源抗菌肽 LL-37 | Antimicrobial Peptide, LL-37

Defensins and LL-37 play key roles in maintaining mucosal barriers against invasive infection and initiating immune responses after infection or injury to mucosal surfaces.

Defensins在自然界中广泛存在，具有对抗多种病原体的活性。防御素具有直接的抗微生物作用，还调节先天和适应性免疫反应。

LL-37 is a C-terminal peptide proteolytically released from 18 kDa human cathelicidin protein (hCAP18). Chronic infections, inflammation, tissue injury and tissue regeneration are all linked with neoplastic growth, and involve LL-37 antibacterial and immunomodulatory functions. Such a link points to the possible involvement of LL-37 peptide in carcinogenesis. An increasing amount of evidence suggests that LL-37 can have two different and contradictory effects—promotion or inhibition of tumor growth. The mechanisms are tissue-specific, complex, and depend mostly on the ability of LL-37 to act as a ligand for different membrane receptors whose expression varies on different cancer cells. Overexpression of LL-37 was found to promote development and progression of ovarian, lung and breast cancers, and to suppress tumorigenesis in colon and gastric cancer.

LL-37是从18kDa人组织蛋白酶蛋白（hCAP18）蛋白水解释放的C末端肽。慢性感染、炎症、组织损伤和组织再生都与肿瘤生长有关，并涉及LL-37的抗菌和免疫调节功能。这种联系表明LL-37肽可能参与致癌作用。越来越多的证据表明，LL-37可以具有两种不同且相互矛盾的作用——促进或抑制肿瘤生长。机制是组织特异性的、复杂的，并且主要取决于LL-37作为不同膜受体的配体的能力，所述不同膜受体在不同癌症细胞上的表达不同。发现LL-37的过表达促进卵巢癌、肺癌和乳腺癌的发展和进展，并抑制结肠癌和癌症中的肿瘤发生。

别名：CAP-18;antibacterial peptide LL-37;Cathelicidin LL-37; LL 37; Peptide LL 37 (human gene FALL39 antibacterial)
纯度：>95% 或 >98%
单字母序列：LLGDFFRKSKEKIGKEFKRIVQRIKDFLRNLVPRTES
三字母序列：Leu-Leu-Gly-Asp-Phe-Phe-Arg-Lys-Ser-Lys-Glu-Lys-Ile-Gly-Lys-Glu-Phe-Lys-Arg-Ile-Val-Gln-Arg-Ile-Lys-Asp-Phe-Leu-Arg-Asn-Leu-Val-Pro-Arg-Thr-Glu-Ser
CAS No.: 154947-66-7
分子式：C205H340N60O53
分子量：4493.33
外观：白色粉末

氨基酸组成分析：

引用文献：

 

1，Human defensins and LL-37 in mucosal immunity 
Mona Doss,   Mitchell R White,   Tesfaldet Tecle,   Kevan L Hartshorn
Journal of Leukocyte Biology, Volume 87, Issue 1, Jan 2010, Pages 79–92

2，The Role of Cathelicidin LL-37 in Cancer Development
Ewelina Piktel, Katarzyna Niemirowicz, Urszula Wnorowska1, Marzena Wątek, Tomasz Wollny, Katarzyna Głuszek, Stanisław Góźdź, Ilya Levental & Robert Bucki 

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