Isochlorogenic acid A | 异绿原酸 A _ MedChemExpress (MCE)

MCE 国际站：Isochlorogenic acid A

参考详情：Isochlorogenic acid A (3,5-Dicaffeoylquinic acid，异绿原酸 A) - 仅供科研 | 抗氧化剂 | MCE

中文名：异绿原酸 A

CAS：2450-53-5

品牌：MedChemExpress (MCE)

存储条件：Powder: -20°C, 3 years; 4°C, 2 years.In solvent: -80°C, 6 months; -20°C, 1 month.

生物活性： Isochlorogenic acid A (3,5-Dicaffeoylquinic acid) 是一种天然酚酸，具有抗氧化和抗炎活性。

体外：Isochlorogenic acid A 抑制 Giardia lamblia (GlLeuRS) 的 LeuRS 氨酰化活性，IC50 为 5.82 μg/mL[1]。 Isochlorogenic acid A (5-100 μM，48 小时) 可增加 B16 细胞中的黑色素含量，并增加 TYR 蛋白活性[4]。 Isochlorogenic acid A 显示 DPPH (IC50=4.26 µg/mL)、ABTS 自由基清除活性[6]。 Isochlorogenic acid A (0-250 μg/mL，24 小时) 抑制 LPS 刺激的 RAW 264.7 细胞中一氧化氮的产生[6]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only.

体内：Isochlorogenic acid A (5 和 10 mg/kg，口服，每天一次，持续 3 周) 可改善 ICR 雄性小鼠 TMT 诱导的认知障碍[5]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: TMT-induced ICR male mice[5] Dosage: 5 and 10 mg/kg Administration: p.o., once a day for 3 weeks Result: Improved spatial memory and learning ability of mice in MWM test. Reduced the TMT-induced increased AChE activity. Reduced the MDA content compared to the TMT group.

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研究领域：Immunology/Inflammation  |  NF-κB  |  Metabolic Enzyme/Protease  |  Anti-infection

作用靶点：Reactive Oxygen Species  |  HBV  |  Endogenous Metabolite  |  HIV  |  Bacterial

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参考文献：

[1]. Zhang YH, et al. 3,5-Dicaffeoylquinic acid isolated from Artemisia argyi and its ester derivatives exert anti-leucyl-tRNA synthetase of Giardia lamblia (GlLeuRS) and potential anti-giardial effects. Fitoterapia. 2012 Oct;83(7):1281-5.[2]. Malarz J, et al. Long-term cultured hairy roots of chicory-a rich source of hydroxycinnamates and 8-deoxylactucin glucoside. Appl Biochem Biotechnol. 2013 Dec;171(7):1589-601.[3]. Wan C, et al. Isolation and identification of phenolic compounds from Gynura divaricata leaves. Pharmacogn Mag. 2011 Apr;7(26):101-8.[4]. Mamat N, et al. Isochlorogenic acid A promotes melanin synthesis in B16 cell through the β-catenin signal pathway. Acta Biochim Biophys Sin (Shanghai). 2017 Sep 1;49(9):800-807. [5]. Kang JY, et al. Reversal of Trimethyltin-Induced Learning and Memory Deficits by 3,5-Dicaffeoylquinic Acid. Oxid Med Cell Longev. 2016;2016:6981595.[6]. Hong, S., et al. Antioxidant and anti-inflammatory activities of 3,5-dicaffeoylquinic acid isolated from Ligularia fischeri leaves. Food Sci Biotechnol 24, 257–263 (2015).