CAS:759-05-7
品牌:MedChemExpress (MCE)
存储条件:Pure form: -20°C, 3 years; 4°C, 2 years.In solvent: -80°C, 6 months; -20°C, 1 month.
生物活性:3-Methyl-2-oxobutanoic acid 是 Escherichia coli 中泛酸的前体。
体外:3-Methyl-2-oxobutanoic acid (alpha-Ketoisovaleric acid) 是 Escherichia coli[1] 中泛酸的前体。 3-甲基-2-氧代丁酸(α-酮异戊酸)增强α-酮异己酸和α-酮-β-甲基-正戊酸,但减少相应的氨基酸,并导致鸟氨酸的早期下降以及血浆精氨酸的晚期增加[2]。
体内:3-Methyl-2-oxobutanoic acid (alpha-Ketoisovaleric acid) 通过 GABAergic 和 glutamatergic 机制诱导大鼠惊厥[3]。
参考详情:https://www.medchemexpress.com/3-Methyl-2-oxobutanoic_acid.html
参考文献:
[1]. MAAS WK, et al. alpha-Ketoisovaleric acid, a precursor of pantothenic acid in Escherichia coli. J Bacteriol. 1953 Apr;65(4):388-93.
[2]. Schauder P, et al. Oral administration of alpha-ketoisovaleric acid or valine in humans: blood kinetics and biochemical effects. J Lab Clin Med. 1984 Apr;103(4):597-605.
[3]. Coitinho AS, et al. Pharmacological evidence that alpha-ketoisovaleric acid induces convulsions through GABAergic and glutamatergic mechanisms in rats. Brain Res. 2001 Mar 9;894(1):68-73.