英文名:Caerulein,FI-6934,CERULEIN,CAERULEIN,CERULETIDE
中文名:雨蛙素,蓝肽,雨蛙肽,硫酸化蓝肽
CAS:17650-98-5
熔点:224-226° (dec)
比旋光度:D20 -26° (c = 1 in DMF)
酸度系数:(pKa)-4.17±0.18(Predicted)
密度:1.464±0.06 g/cm3(Predicted)
Molecular formula:C58H73N13O21S2
Molecular weight:1352.41
Purity:95%+
Appearance:solid/powder
Matters for use:
It is sensitive to light and temperature. In order to use the reagent effectively, the material should always be kept in a low temperature dry condition, away from light, and avoid frequent thawing and freezing.
storage conditions:
Store at - 20 ℃ as much as possible. If conditions permit, the material can be treated under inert gas to obtain better stability of the reagent.
Packing specification:1g,5g,10g
结构式:
产品介绍:
雨蛙素(Caerulein),又名雨蛙肽,是澳大利亚产的蛙HYlaCaerulea的皮肤提取物,由10个氨基酸组成。是以三氟醋酸盐形式提供的十肽分子,为胆囊收缩素类似物,作用于胰腺腺泡细胞,可引起大量消化酶和胰液的分泌,从而导致急性水肿性胰腺炎。雨蛙素可用于研究由NF-κB上调蛋白如细胞间黏附分子(ICAM-1),炎症相关因子如NADPH氧化酶以及Janus激酶介导的信号转导途径。已经成功运用于大鼠、小鼠、狗和叙利亚仓鼠等动物急性胰腺炎(AP)模型的建立。
母液配制方法。先用无氧蒸馏水或最好用无菌的无氧水来溶解多肽,如有必要加入约1%的稀醋酸或氢氧化铵来促进溶解。(少数情况下以上方式可能都无法溶解充分,可对溶液进行短暂超声处理(10min,温度不超过30-40℃))。多肽充分溶解后,加入缓冲液或生理盐水稀释到1 mg/mL配制储存液。
(文章资料汇总来源于:陕西新研博美生物科技有限公司小编木木)
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备注:本产品仅用于科研,不能用于人体治疗或家庭备药。