中文名:PSMA617
英文名:Vipivotide tetraxetan
PSMA617 TFA
4YM1W0EGQ5
Vipivotide tetraxetan [INN]
Vipivotide tetraxetan [USAN]
Vipivotide tetraxetan (USAN/INN)
CAS:1702967-37-0
沸点:1371.9±65.0 °C
密度:1.322±0.06 g/cm3
酸度系数(pKa):1.83±0.10
一、Product parameters:
1.Molecular formula:C49H71N9O16
2.Molecular weight:1042.14
3.Packaging specification:1g、5g、10g, flexible packaging, including 100mg packaging and 500mg 1g and 5g large packaging
Product structure:
二、Reaction characteristics:
Vipivotide tetraxetan (PSMA-617) 是前列腺特异性膜抗原 (PSMA) 的强有效抑制剂。Vipivotide tetraxetan (PSMA-617)由三种成分组成:药效基团Glutamate-urea-Lysine,螯合剂DOTA(能够结合68Ga或177Lu),以及连接这两个实体的linker。DOTA是使大多数辐射计复杂化的金标准。在螯合剂和生物载体之间找到正确的组合是很重要的。
Vipivotide tetraxetan是一种四价融合蛋白,它结合了免疫球蛋白G(IgG)和凝血因子X(FX),以及两种不同的细胞因子受体,即肿瘤坏死因子受体(TNF-R)和干扰素-gamma受体(IFN-gamma-R)。 Vipivotide tetraxetan的主要作用机制是通过与细胞因子的受体结合,抑制炎症和免疫反应,从而减少对患者的损害。其中,IgG和FX的结合能够增强药物的稳定性和溶解度,使其在体内更加稳定和有效。
(上述信息均由陕西新研博美生物科技有限公司的小编木木所整理)
三、Matters for use:
It is sensitive to light and temperature. In order to use the reagent effectively, the material should always be kept in a low temperature dry condition, away from light, and avoid frequent thawing and freezing.
四、storage conditions:
Store at - 20 ℃ as much as possible. If conditions permit, the material can be treated under inert gas to obtain better stability of the reagent.
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