Bioinformatics 笔记

    
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BIOINFORMATICS ALGORITHMS,VOL.I By 作者: Phillip Compeau – Pavel Pevzner ISBN-10 书号: 0990374610 ISBN-13 书号: 9780990374619 Edition 版本: 2nd 出版日期: 2015 pages 页数: 384 Overview Contents List of Code Challenges About the Textbook Chapter 1:Where in the Genome Does DNA Replication Begin? Chapter 2:Which DNA Patterns Play the Role of Molecular Clocks? Chapter 3:How Do We Assemble Genomes? Chapter 4:How Do We Sequence Antibiotics? Chapter 5:How Do We Compare DNA Sequences? Chapter 6:Are There Fragile Regions in the Human Genome? Bibliography mage Courtesies This is Vol. 1 of Bioinformatics Algorithms: an Active Learning Approach, one of the first textbooks to emerge from the recent Massive Open Online Course MOOC revolution. A light hearted and analogy filled companion to the author’s acclaimed Bioinformatics Specialization on Coursera, this book presents students with a dynamic approach to learning bioinformatics. It strikes a unique balance between practical challenges in modern biology and fundamental algorithmic ideas, thus capturing the interest of students of both biology and computer science. Each chapter begins with a biological question, such as Are There Fragile Regions in the Human Genome or Which DNA Patterns Play the Role of Molecular Clocks and then steadily develops the algorithmic sophistication required to answer this question. Hundreds of exercises are incorporated directly into the text as soon as they are needed; readers can test their knowledge through automated coding challenges on the Rosalind Bioinformatics Textbook Track.
This practical book teaches the skills that scientists need for turning large sequencing datasets into reproducible and robust biological findings. Many biologists begin their bioinformatics training by learning scripting languages like Python and R alongside the Unix command line. But there's a huge gap between knowing a few programming languages and being prepared to analyze large amounts of biological data. Rather than teach bioinformatics as a set of workflows that are likely to change with this rapidly evolving field, this book demsonstrates the practice of bioinformatics through data skills. Rigorous assessment of data quality and of the effectiveness of tools is the foundation of reproducible and robust bioinformatics analysis. Through open source and freely available tools, you'll learn not only how to do bioinformatics, but how to approach problems as a bioinformatician. Go from handling small problems with messy scripts to tackling large problems with clever methods and tools Focus on high-throughput (or "next generation") sequencing data Learn data analysis with modern methods, versus covering older theoretical concepts Understand how to choose and implement the best tool for the job Delve into methods that lead to easier, more reproducible, and robust bioinformatics analysis Table of Contents Part I. Ideology: Data Skills for Robust and Reproducible Bioinformatics Chapter 1. How to Learn Bioinformatics Part II. Prerequisites: Essential Skills for Getting Started with a Bioinformatics Project Chapter 2. Setting Up and Managing a Bioinformatics Project Chapter 3. Remedial Unix Shell Chapter 4. Working with Remote Machines Chapter 5. Git for Scientists Chapter 6. Bioinformatics Data Part III. Practice: Bioinformatics Data Skills Chapter 7. Unix Data Tools Chapter 8. A Rapid Introduction to the R Language Chapter 9. Working with Range Data Chapter 10. Working with Sequence Data Chapter 11. Working with Alignment Data Chapter 12. Bioinformatics Shell Scripting, Writing Pipelines, and Parallelizing Tasks Chapter 13. Out-of-Memory Approaches: Tabix and SQLite Chapter 14. Conclusion

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