MCE 国际站:Inosine
参考详情:Inosine (肌苷) - 仅供科研 | 内源性代谢物 | MCE
中文名:肌苷
CAS:58-63-9
品牌:MedChemExpress (MCE)
存储条件:Powder: -20°C, 3 years; 4°C, 2 years.In solvent: -80°C, 6 months; -20°C, 1 month.
生物活性:肌苷是由腺苷分解代谢产生的内源性嘌呤核苷。肌苷具有抗炎、镇痛、免疫调节和神经保护作用。肌苷是腺苷 A1 (A1R) 和 A2A (A2AR) 受体[1][2][3]。
体外:肌苷剂量依赖性地刺激通过 A2AR[2] 介导的 cAMP 产生。
肌苷剂量依赖性地诱导 hA2AR介导的 ERK1/2 磷酸化[2]。
肌苷(100 μM;24 小时)减少用星形胶质细胞培养的 MES 23.5 细胞的氧化应激[3]。
体内:肌苷 (10-100 mg/kg; ip) 对小鼠具有镇痛作用[2]。
热销产品:Coelenterazine | Isoprenaline (hydrochloride) | Sacituzumab govitecan | Inavolisib | Celastrol | Tacrolimus | Pertuzumab | Fulvestrant | U0126-EtOH | 4-Azido-L-phenylalanine
研究领域:GPCR/G Protein | Metabolic Enzyme/Protease
作用靶点:Adenosine Receptor | Endogenous Metabolite
Trending products:Recombinant Proteins | Bioactive Screening Libraries | Natural Products | Fluorescent Dye | PROTAC | Isotope-Labeled Compounds | Oligonucleotides
参考文献:
[1]. Filipe Marques Gonçalves, et al. Signaling pathways underlying the antidepressant-like effect of inosine in mice. Purinergic Signal. 2017 Jun; 13(2): 203-214.
[2]. Ajith A. Welihinda, et al. The adenosine metabolite inosine is a functional agonist of the adenosine A2A receptor with a unique signaling bias. Cell Signal. 2016 Jun; 28(6): 552-560.
[3]. Francisney Pinto Nascimento, et al. Adenosine A1 receptor-dependent antinociception induced by inosine in mice: pharmacological, genetic and biochemical aspects. Mol Neurobiol. 2015;51(3):1368-78.
[4]. Sara Cipriani, et al. Protection by inosine in a cellular model of Parkinson’s disease. Neuroscience. 2014 Aug 22; 274: 242-249.