芦丁 (Rutoside) 是一种在许多植物中发现的类黄酮，具有广泛的生物活性，包括抗炎、抗糖尿病、抗氧化、神经保护、肾保护、保肝和降低 Aβ 寡聚体活性

参考详情：Rutin (Rutoside，芦丁) - 仅供科研 | CBR1抑制剂 | MCE

中文名：芦丁

CAS：153-18-4

品牌：MedChemExpress (MCE)

存储条件：Powder: -20°C, 3 years; 4°C, 2 years.In solvent: -80°C, 6 months; -20°C, 1 month.

生物活性：芦丁 (Rutoside) 是一种在许多植物中发现的类黄酮，具有广泛的生物活性，包括抗炎、抗糖尿病、抗氧化、神经保护、肾保护、保肝和降低 Aβ 寡聚体活性。芦丁可以穿过血脑屏障。芦丁通过抑制细胞凋亡、线粒体功能障碍和氧化应激来减轻万古霉素诱导的肾小管细胞凋亡[1][2][3] . 

体内：芦丁水合物通过提高乙酰胆碱水平、抑制 JNK 和 ERK1/2 激活以及激活 mTOR 信号通路来改善氯化镉诱导的大鼠空间记忆丧失和神经细胞凋亡[4]。

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研究领域：Neuronal Signaling  |  Autophagy  |  Apoptosis  |  Metabolic Enzyme/Protease

作用靶点：Amyloid-β  |  Autophagy  |  Apoptosis  |  Endogenous Metabolite

Trending products：Recombinant Proteins  |  Bioactive Screening Libraries  |  Natural Products  |  Fluorescent Dye  |  PROTAC  |  Isotope-Labeled Compounds  |  Oligonucleotides

参考文献：

[1]. Ghorbani A. Mechanisms of antidiabetic effects of flavonoid rutin. Biomed Pharmacother. 2017;96:305-312.

[2]. Habtemariam S. Rutin as a Natural Therapy for Alzheimer's Disease: Insights into its Mechanisms of Action. Curr Med Chem. 2016;23(9):860-873.

[3]. Xu PX, et al. Rutin improves spatial memory in Alzheimer's disease transgenic mice by reducing Aβ oligomer level and attenuating oxidative stress and neuroinflammation. Behav Brain Res. 2014;264:173-180.

[4]. Abdel-Aleem GA, et al. Rutin hydrate ameliorates cadmium chloride-induced spatial memory loss and neural apoptosis in rats by enhancing levels of acetylcholine, inhibiting JNK and ERK1/2 activation and activating mTOR signalling. Arch Physiol Biochem. 2018;124(4):367-377.

[5]. Carlquist M, et al. Flavonoids as inhibitors of human carbonyl reductase 1. Chem Biol Interact. 2008 Jul 30;174(2):98-108.